开发含有可纳和硫醇的生物聚合物薄膜,用于抵抗性阴道白症
Júlia Conte1, Rodrigo Henrique Saatkamp2, Mariele Paludetto Sanches2
1Postgraduate Program in Pharmacy (PGFAR), Federal University of Santa Catarina, Trindade, 88040-900 Florianopolis, SC, Brazil.
International journal of biological macromolecules
|June 30, 2024
概括
新的阴道膜结合了弗卢科纳和提摩尔,可以有效治疗耐药性vulvovaginal candidiasis (VVC). 这种局部方法可以增强药物输送和抗真菌活性,为口服疗法提供了一个有前途的替代方案.
科学领域:
- 制药技术 制药技术 制药技术
- 菌类学 菌类学是指菌类学.
- 生物材料科学 生物材料科学
背景情况:
- Vulvovaginal candidiasis (VVC) 影响了大多数女性,口服疗法面临着由真菌耐药性和不良影响带来的挑战.
- 开发新型药物输送系统对于提高VVC治疗疗效和患者服药性至关重要.
研究的目的:
- 开发和评估新型局部阴道薄膜,含有可纳 (FLU) 和硫醇 (THY) 用于治疗VVC.
- 克服与口服抗真菌疗法相关的挑战,包括耐药性和副作用.
主要方法:
- 使用单独或与pectin (PEC) 或hydroxypropylmethylcellulose acetate succinate (HPMCAS) 结合使用奇托 (CH) 通过溶剂造开发阴道膜.
- 薄膜属性的表征,包括膨胀指数,可塑性和灵活性.
- 评估流可纳 (FLU) 和硫醇 (THY) 在阴道组织中的释放,透性和分布.
- 对Candida物种的抗真菌活性的评估,包括像C. glabrata这样的耐药菌株.
主要成果:
- 与其他配方相比,奇托桑/HPMCAS薄膜表现出优越的膨胀,可塑性和灵活性.
- 固定性流纳 (FLU) 在接触阴道液时表现出高透率和快速凝形成.
- 乙醇 (THY) 增强了阴道组织中的FLU分布,并改善了抗Candida活性.
- 对抗抗药性*C. glabrata*所需的FLU剂量的显著降低 (降低了50%).
结论:
- 含有可纳 (FLU) 和硫醇 (THY) 的聚合物薄膜具有显著的潜力,可以作为对性阴道白症 (VVC) 的局部治疗.
- 这种配方有效地解决药物耐药性问题,并与口服疗法相比提供了改进的输送方法.
- 需要进一步的研究来探索这些有前途的阴道膜的临床应用.
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