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Updated: Jun 22, 2025

Reporter-based Growth Assay for Systematic Analysis of Protein Degradation
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蛋白质质量控制降解的UPS依赖的策略

Leonie Müller1, Thorsten Hoppe1

  • 1Institute for Genetics, University of Cologne, 50674 Cologne, Germany; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, 50931 Cologne, Germany; Center for Molecular Medicine Cologne (CMMC), Faculty of Medicine and University Hospital of Cologne, 50931 Cologne, Germany.

Trends in biochemical sciences
|June 30, 2024
PubMed
概括

蛋白质降解对健康至关重要,防止有毒聚合物. 专门的E3链酶控制这个过程,但区分受损的蛋白质和暂时错误折叠的蛋白质仍然是蛋白质质量控制 (PQC) 中的一个关键挑战.

关键词:
E3 无处不在的合酶降级 degron 降级 降低 降低分子陪伴者是一个分子陪伴者.蛋白质损伤 蛋白质损伤蛋白质稳定性 蛋白质稳定性无处不在的蛋白酶体系统 (UPS)

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