相关实验视频

Updated: May 9, 2026

Isolation of Adipose Tissue Immune Cells

Isolation of Adipose Tissue Immune Cells

Published on: May 22, 2013

脂肪干细胞驱动肥胖症T细胞透

Aneta Balcerczyk¹, Assia Eljaafari², Luciano Pirola³

¹Department of Oncobiology and Epigenetics, Faculty of Biology and Environmental Protection, University of Lodz, Pomorska 141/143, Lodz 90-236, Poland.

Trends in endocrinology and metabolism: TEM

|June 30, 2024

概括

与肥胖相关的脂肪组织炎症涉及T细胞透. 研究人员发现,分泌C-C动机化学因子连接体5 (CCL5) 的脂肪干细胞对于这一过程至关重要,这表明了新的治疗点.

科学领域:

免疫学免疫学免疫学
代谢性疾病研究研究.
细胞生物学细胞生物学

背景情况:

肥胖经常伴随着脂肪组织 (AT) 内的炎症,其特点是免疫细胞的透.
了解驱动AT免疫细胞透的细胞和分子机制对于解决与肥胖有关的并发症至关重要.

研究的目的:

研究T细胞透到脂肪组织的机制.
确定关键的细胞参与者和参与肥胖期间AT炎症的信号通路.

主要方法:

单细胞RNA测序 (scRNA-seq) 用于分析AT的细胞组成和基因表达.
使用了移植研究,体外共同培养实验和淘汰小鼠模型的使用.
研究了特定的化学激素和细胞类型在免疫细胞招募中的作用.

主要成果:

脂肪干细胞 (ASC) 被确定为C-C动机化学因子连接体5 (CCL5) 的关键来源.
由ASCs分泌的CCL5在吸引和促进T细胞透到脂肪组织中起着至关重要的作用.
该研究阐明了在AT炎症的背景下,ASCs,CCL5和T细胞招募之间的特定机制.

结论:

分泌CCL5的脂肪干细胞是T细胞透到脂肪组织的关键驱动因素.
针对涉及ASC的CCL5介导途径,可能为与肥胖相关的脂肪组织炎症提供新的治疗策略.

更多相关视频

Characterization of Immune Cells in Human Adipose Tissue by Using Flow Cytometry

Characterization of Immune Cells in Human Adipose Tissue by Using Flow Cytometry

Published on: March 6, 2018

Isolation, Expansion, and Adipogenic Induction of CD34+CD31+ Endothelial Cells from Human Omental and Subcutaneous Adipose Tissue

Isolation, Expansion, and Adipogenic Induction of CD34+CD31+ Endothelial Cells from Human Omental and Subcutaneous Adipose Tissue

Published on: July 17, 2018

相关概念视频

Obesity

Obesity

The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in adipocytes...