药物相互作用来源的评估 尼尔马特雷尔维尔/里托纳维尔的药物相互作用信息
Hiroshi Yoshikawa1, Takashi Tomita1, Erika Shigita1
1Department of Pharmaceutical Services, Hiroshima University Hospital.
概括
日本的尼玛特里尔维尔/里托纳维尔包装说明书中存在药物相互作用信息缺口. 咨询Lexicomp或JSPHCS等多个来源对于安全的临床管理至关重要,因为信息的一致性很低.
科学领域:
- 药理学 药理学是指药理学的学科.
- 药物相互作用 药物相互作用
- 临床药房 临床药房
背景情况:
- 日本包装说明书 (J-PI) 尼马特里尔维尔/里托纳维尔 (N/r) 含有众多药物相互作用警告.
- 在J-PI药物相互作用信息和外国数据库之间存在差异,这可能会影响患者的安全.
研究的目的:
- 评估和比较有关涅马特里尔维尔/里托纳维尔药物相互作用的各种信息来源.
- 与国际资源相比,确定J-PI中缺少的禁忌和预防措施.
主要方法:
- 来自J-PI,外国监管机构和专业数据库 (NIH,UHN,安大略省COVID-19科学咨询表,利物浦大学,Lexicomp,JSPHCS) 的N/r药物相互作用数据的比较分析.
- 评估信息量,缺少数据,N/r和同时使用药物的曲线下面积 (AUC) 预测变化,以及来源一致性.
主要成果:
- 一个数据集确定了N/r同时使用的115个禁忌和203个预防措施.
- 在J-PI中缺少51个禁忌,包括9种具有显著预测AUC变化 (≥5倍或<1/5基线) 的药物.
- 在信息来源中观察到的一致性很低.
结论:
- 单独的J-PI可能无法提供足够的信息来管理nirmatrelvir/ritonavir药物相互作用.
- 莱克西康普和JSPHCS提供了广泛的数据和覆盖范围,用于具有实质性AUC变化的药物.
- 由于来源一致性较低,临床管理需要咨询多个信息来源.
相关概念视频
Pharmacovigilance
817
Post-marketing surveillance is a critical component of pharmaceutical regulation, often uncovering unanticipated adverse drug reactions (ADRs) once a drug is widely used over an extended period.
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...
817
Quantitative Aspects of Drug-Receptor Interaction
972
The receptor occupancy theory connects a drug's response to the number of occupied receptors. With higher drug concentrations, more receptors are occupied, leading to increased responses. The formation of drug-receptor complexes involves association and dissociation rates, which reach equilibrium when the forward and backward reactions are equal. The equilibrium association constant (Ka) and its inverse, the equilibrium dissociation constant (Kd), indicate drug affinity. Higher Ka and lower...
972
Drug-Receptor Interactions
5.1K
Drug-receptor interaction describes the binding of receptors by drugs, but not all drug-receptor interactions result in activation and tissue response. For instance, the binding of agonists activates the receptor to generate a cellular reaction, while antagonists bind to receptors without causing their activation.
Several parameters, such as the drug's affinity for its receptor and its efficacy, which is its ability to activate the receptor, determine the drug's effect on the tissue....
Several parameters, such as the drug's affinity for its receptor and its efficacy, which is its ability to activate the receptor, determine the drug's effect on the tissue....
5.1K
Combined Effects of Drugs: Antagonism
8.4K
The combined effects of drugs can result in various interactions, of which an important type is antagonism. Antagonism is a mechanism where one drug inhibits or counteracts the effects of another drug. Antagonism can occur through various means, including receptor binding, allosteric modulation, functional interaction, chemical reactions, and pharmacokinetic processes.
The most common type is receptor antagonism, where one drug acts as an antagonist to block the effects of another drug by...
The most common type is receptor antagonism, where one drug acts as an antagonist to block the effects of another drug by...
8.4K
Therapeutic Index
4.2K
The therapeutic index of a drug is a key parameter in pharmacology that quantifies the relative safety of a drug by calculating the ratio between the dose that causes toxicity in half the population (50%) to the dose that proves to be effective for half the population (50%). It provides a spectrum of doses for a particular drug ranging from effective to potentially toxic. To illustrate, consider an anticoagulant agent like warfarin. It possesses a narrow window within its therapeutic index to...
4.2K
Combined Effects of Drugs: Synergism
3.8K
Synergism is a useful mechanism where combining two or more drugs is more effective than each constituent used alone. Such combinations are also called supra-additive interactions. The drugs collectively enhance the final therapeutic effect by acting on different targets. Another advantage is that the low dose of each constituent drug is sufficient to achieve the desired effect. This helps reduce the duration of therapy and lower the adverse effects of these drugs.
Such synergistic combinations...
Such synergistic combinations...
3.8K


