脑下垂体手术后患有库辛病的患者与非功能性脑下垂体腺瘤的长期结果:一个活体-比较队列研究
Sara Germann1, Roxana Wimmer1,2, Rahel Laager2
1University Department of Medicine, Clinic for Endocrinology, Diabetology, and Metabolism, Kantonsspital Aarau, 5001 Aarau, Switzerland.
European journal of endocrinology
|July 1, 2024
概括
与非功能性垂体腺瘤 (NFPA) 患者相比,患有库辛病 (CD) 的患者在垂体外科手术后面临更高的并发症风险. 这些风险包括精神病医院住院和败血症,表明恢复不完全.
科学领域:
- 内分泌学 在内分泌学.
- 神经外科 神经外科
- 在瘤学瘤学.
背景情况:
- 库辛病 (CD) 往往导致多系统发病,在治疗后可能不会完全消失.
- 下垂体手术是CD的首要治疗方法,但长期结果需要进一步调查.
研究的目的:
- 为了比较住院患者患有库辛病 (CD) 的重大并发症的发病率与下垂体手术后非功能性下垂体腺瘤 (NFPA) 的发病率.
- 评估CD对手术干预后患者发病率的长期影响.
主要方法:
- 一项基于人口的回顾性队列研究利用了瑞士联邦统计局 (2012-2021) 的数据.
- 倾向性得分匹配 (1:5) 与住院CD患者和接受垂体外科手术的NFPA患者进行比较.
- 主要复合终点包括死亡率,主要心脏不良事件,精神病医院住院,败血症,血栓栓塞事件和骨折.
主要成果:
- 在手术后分析了116名CD患者和396名NFPA患者 (随访时间中位数:50.0个月).
- 慢性病患者表现出主要复合终点 (HR 2.75) 的发生率显著更高.
- 在CD患者中观察到精神疾病住院率增加 (HR 3.27) 和败血症的趋势.
结论:
- 库辛病患者在下垂体手术后出现严重并发症的风险要大得多.
- 精神病医院住院和败血症在CD患者中代表了显著的术后发病率.
- 这些发现强调了即使在成功的垂体外科手术后,也需要对CD患者进行警的监测和管理.
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