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Updated: Jun 22, 2025
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Human Egg Maturity Assessment and Its Clinical Application
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在接受IVF卵巢刺激的患者中预测LH过早升高的临床参数
Maya Nasatzky1,2, Yonathan Belicha1,2, Ofer Fainaru1,2
1IVF Unit, Rambam Medical Center, Haifa, Israel.
概括
使用患者数据,可以预测体外受精 (IVF) 期间黄质激素 (LH) 过早升高. 这种模型可以帮助防止周期取消,并优化排卵触发,以获得更好的试管婴儿结果.
科学领域:
- 生殖内分泌学和不孕不育问题
- 在体外受精 (IVF) 协议.
- 辅助生殖中的荷尔蒙调节
背景情况:
- 卵泡刺激激素 (FSH) 和黄素化激素 (LH) 的适当调节对于正常的生殖功能至关重要.
- 在试管婴儿中卵巢刺激期间LH提升过早,尽管使用性腺激素释放激素 (GnRH) 抗剂,但可能需要取消周期.
- 以前的研究表明,LH过早升高和卵巢对淋巴激素的反应之间存在联系.
研究的目的:
- 确定可以预测IVF期间LH过早升高的临床参数.
- 确定这些参数对预测LH提升过早的相对贡献.
- 开发一种预测模型,用于识别患有LH过早升高风险的患者.
主要方法:
- 这是一项回顾性研究,涉及382名接受试管婴儿治疗的患者.
- 患者分层分成年龄组进行分析.
- 使用多重线性回归和基于临床和人口参数的机器学习算法的预测模型的开发.
主要成果:
- 增加LH的关键预测因素包括患者年龄,BMI,基线LH,对抗剂当天的LH和刺激持续时间.
- 预测模型在年轻患者 (25-30岁;R2 = 0.88) 中显示出最高的准确性,在老年患者 (>41岁;R2 = 0.23) 中显示出最低的准确性.
- 升的LH被量化为触发前和基底LH水平之间的差异.
结论:
- 结合多重线性回归和机器学习的预测模型可以识别在IVF期间患有LH过早升高或激增风险的患者.
- 这种预测能力可能有助于防止IVF周期取消.
- 该模型支持优化排卵触发时间,以提高试管婴儿成功率.
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