相关实验视频

Updated: May 5, 2026

An Optimized Hemagglutination Inhibition HI Assay to Quantify Influenza-specific Antibody Titers

An Optimized Hemagglutination Inhibition HI Assay to Quantify Influenza-specific Antibody Titers

Published on: December 1, 2017

perfluoroalkyl物质 (PFAS) 的二进制和四进制混合物不同地影响对流感A病毒感染的免疫反应

Christina M Post¹, Carrie McDonough², B Paige Lawrence¹

¹University of Rochester School of Medicine & Dentistry, Rochester, NY.

Journal of immunotoxicology

|July 1, 2024

概括

和多醇基物质 (PFAS) 混合物可以抑制免疫功能,在流感A病毒感染期间影响T细胞和B细胞的反应. 这些发现凸显了联合暴露于PFAS的复杂,非添加剂的免疫毒性影响.

科学领域:

环境化学环境化学
免疫毒理学免疫毒理学
公共卫生公共卫生

背景情况:

和多基基物质 (PFAS) 是持久的,生物累积的环境污染物.
人类广泛暴露于PFAS是有记录的,免疫抑制是一个一致的健康影响.
关于PFAS混合物的免疫毒性研究有限,特别是在感染的背景下.

研究的目的:

用小鼠模型研究PFAS混合物的免疫毒性作用.
评估暴露于二进制和四进制PFAS混合物后对A型流感病毒 (IAV) 感染的免疫反应.

主要方法:

小鼠被暴露在含有PFAS的二元混合物 (PFOS/PFOA) 或四元混合物 (PFOS/PFOA/PFHxS/PFNA) 的饮用水中.
随后,小鼠被感染了A型流感病毒 (IAV).
分析了免疫细胞的反应,特别是T细胞和B细胞的功能.

主要成果:

暴露于二元PFAS混合物改变了T细胞对IAV感染的反应.
暴露于四级PFAS混合物影响了B细胞对IAV感染的反应.
PFAS混合物的免疫调节作用不是附加的,表明细胞类型的特定敏感性.

结论:

PFAS混合物表现出复杂的免疫调节作用,因混合物成分和免疫细胞类型而异.
该研究强调了评估现实世界PFAS混合物的不良健康影响的重要性.
了解混合物毒性对于准确评估PFAS等环境污染物的风险至关重要.

关键词:

perfluoroalkyl 物质 (PFAS) 是一种含有高酸的物质.免疫系统是免疫系统的.流感流感流感流感流感混合物混合物混合物

更多相关视频

A Method to Assess Fc-mediated Effector Functions Induced by Influenza Hemagglutinin Specific Antibodies

A Method to Assess Fc-mediated Effector Functions Induced by Influenza Hemagglutinin Specific Antibodies

Published on: February 23, 2018

Evaluation of T Follicular Helper Cells and Germinal Center Response During Influenza A Virus Infection in Mice

Evaluation of T Follicular Helper Cells and Germinal Center Response During Influenza A Virus Infection in Mice

Published on: June 27, 2020

相关概念视频

Viral Recombination

Viral Recombination

Cells are sometimes infected by more than one virus at once. When two viruses disassemble to expose their genomes for replication in the same cell, similar regions of their genomes can pair together and exchange sequences in a process called recombination. Alternatively, viruses with segmented genomes can swap segments in a process called reassortment.

Leaky Scanning

Leaky Scanning

During most eukaryotic translation processes, the small 40S ribosome subunit scans an mRNA from its 5' end until it encounters the first start AUG codon. The large 60S ribosomal subunit then joins the smaller one to initiate protein synthesis. The location of the translation initiation is largely determined by the nucleotides near the start codon as there may be multiple translation initiation sites present on the mRNA. Marilyn Kozak discovered that the sequence RCCAUGG (where R...

Influenza

Influenza

Influenza is an acute, highly communicable viral disease that affects the respiratory tract and is responsible for seasonal epidemics worldwide. Influenza A is the most prevalent type associated with widespread outbreaks and is subtyped based on two surface glycoproteins: hemagglutinin (H) and neuraminidase (N), as in H1N1. These glycoproteins are essential for viral infectivity, transmission, and immune recognition. Transmission occurs primarily through respiratory droplets and contaminated...