甲状腺超声波变化与甲状腺自身免疫性,经过体外受精/细胞内质精子注射的甲状腺女性的植入失败有关
Jiahui Wang1,2,3,4,5,6,7, Wei Zhou1,2,3,4,5,6, Jincheng Li1,2,3,4,5,6
1Center for Reproductive Medicine, Shandong University, Jinan, Shandong, China.
概括
患有甲状腺自身免疫 (TAI) 的甲状腺女性接受IVF/ICSI,其植入率较低,特别是那些超声波检测到的哈西摩托症患者.
科学领域:
- 生殖内分泌学和不孕不育问题
- 甲状腺学 甲状腺学
- 医学超声波 医学超声波
背景情况:
- 甲状腺自身免疫 (TAI) 在生殖年龄的女性中很普遍.
- TAI对体外受精 (IVF) 结果的影响仍然是研究的主题.
- 哈西莫托甲状腺炎 (HT) 是一种常见的TAI形式,其特点是特定的超声检测结果.
研究的目的:
- 调查哈西莫托甲状腺炎 (HT) 的超声波表现与受试管婴儿/ICSI治疗的TAI妇女的胚胎质量或妊娠结果之间的关联.
- 确定HT的特定超声波特征是否会影响植入率和其他IVF/ICSI结果.
主要方法:
- 对589名接受试管婴儿/ICSI (214名TAI,375名对照) 治疗的安甲状腺女性进行了回顾性队列研究.
- 基于血清甲状腺过氧化酶抗体 (TPOAb) 和/或抗甲状腺球蛋白抗体 (TgAb) 的TAI诊断.
- 评估基底激素水平,甲状腺超声波,胚胎质量和妊娠结果;采用了后勤回归分析.
主要成果:
- 与对照组相比,患有TAI的乙甲状腺女性的植入率明显较低 (65.5%vs73.0%).
- 超声波检测到HT形态变化的TAI女性的植入率明显低于对照组 (64.1%vs73.0%).
- 在正常甲状腺超声波和对照的TAI妇女之间没有观察到植入率的显著差异;胚胎质量和怀孕率在不同组之间是可比的.
结论:
- 带有TAI的高甲状腺女性,特别是超声波证明HT的女性,在IVF/ICSI期间面临着植入失败的风险.
- 暗示HT的超声波发现可能是影响TAI妇女植入成功的重要因素.
- 需要进一步的研究,以阐明在无甲状腺性HT患者的植入失败背后的机制.
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