平等性,不孕不育,第一次出生时的年龄和心房动风险:来自HUNT研究的数据
Hikaru Morooka1,2, Eirin B Haug1, Vegard Malmo3,4
1Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, 8905, N-7491 Trondheim, Norway.
European journal of preventive cardiology
|July 1, 2024
概括
较高的平价率,不孕史和初胎年龄较小与45岁以上女性心房动 (AF) 风险增加有关. 这些生殖因素可能会影响心血管健康结果.
科学领域:
- 心脏病学 心脏病学
- 生殖健康 生殖健康
- 流行病学 流行病学
背景情况:
- 心血管疾病风险受到生殖史的影响.
- 关于平价,不孕不育,第一次分娩的年龄和心房动 (AF) 之间的关联的研究是有限的.
研究的目的:
- 为了调查平价,不孕不育,第一次分娩的年龄和发展心房动 (AF) 的风险之间的联系.
主要方法:
- 基于人口的队列研究,将HUNT和挪威医疗出生登记数据联系起来.
- 随访了24015名45岁或以上的女性,平均12.8年时间内对发生的AF进行了随访.
- 使用考克斯的比例危险模型来评估与生殖因素的关联.
主要成果:
- 较高的平价率 (≥4个出生) 与21%的AF风险增加有关.
- 患有不孕症的病史显示,AF的风险增加了20%.
- 第一次出生时的年龄较小 (<20岁) 与AF风险增加20%有关.
结论:
- 在45岁以上的女性中,四次或更多的分娩,不孕或初次分娩年龄较小与约20%的AF风险增加有关.
- 这些生殖特征是绝经后妇女AF的潜在风险因素.
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