心血管疾病的缓解药物治疗:美国心脏协会的科学声明
Circulation. Cardiovascular quality and outcomes
|July 1, 2024
概括
缓解性药物治疗,使用心血管和缓解性药物,可以改善晚期心血管疾病患者的生活质量. 这种方法,包括降级和共享决策,未得到充分利用,但对于症状控制至关重要.
科学领域:
- 心脏病学 心脏病学
- 抚慰性护理是一种缓解性护理.
- 药物治疗 药物治疗
背景情况:
- 心血管疾病 (CVD) 显著影响健康和生活质量,特别是在老年人中.
- 尽管有延长生命的疗法,心血管疾病的进展是不可预测的,导致症状恶化,住院治疗和高医疗费用.
- 与其他严重疾病相比,心血管疾病中使用缓解药物管理不足.
研究的目的:
- 描述心血管疾病的息性药物治疗,整合心血管和息性药物.
- 审查指南导向和基于证据的治疗方法在末期心血管疾病的证据.
- 在息框架内提供关于降低药物升级和降低处方的指导.
主要方法:
- 文献综述和证据综合关于心血管疾病的息性药物治疗.
- 针对末期心力衰竭,肺动脉高血压,冠心病和心肌病的指导方针导向医学疗法的分析.
- 强调共享决策和以目标为导向的护理原则.
主要成果:
- 息性药物治疗,结合心血管和息剂,可以协同控制症状并提高生活质量.
- 证据支持针对晚期心血管疾病的特定医疗疗法,并考虑减缓处方.
- 共享决策对于以患者为中心的药物管理至关重要.
结论:
- 将息性药物治疗整合到心血管护理中,对于症状管理和改善生活质量至关重要.
- 一种以患者为中心的方法,强调共享决策和以目标为导向的护理是必不可少的.
- 进一步的研究和临床采用心血管疾病的息策略是有必要的.
相关概念视频
Cardiovascular Drugs: Classification based on Therapeutic Indications
2.2K
Cardiovascular diseases, encompassing a range of conditions, can significantly affect the heart's operations and the overall circulatory system. These conditions impair the heart's ability to pump blood, leading to a deficit in oxygen supply to crucial organs. Anomalies in the heart's electrical system, known as arrhythmias, can cause heartbeats to accelerate or slow down. Usually, heart rates increase during physical activity and decrease while resting or sleeping. However,...
2.2K
Heart Failure Drugs: Inhibitors of Renin-Angiotensin System
419
The activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system (RAAS) contributes to cardiac remodeling, and inhibiting the RAAS is a pharmacological target in heart failure management. As a result, neurohumoral modulation is a crucial treatment principle for managing heart failure. This approach involves using medications like ACE inhibitors (ACEIs), angiotensin receptor blockers (ARBs), β-blockers, mineralocorticoid receptor antagonists (MRAs), and neutral...
419
Heart Failure Drugs: β-Blockers
336
β-adrenergic antagonists, commonly known as β-blockers, block the effects of sympathetic neurotransmitters such as noradrenaline (NA) and adrenaline (ADR). They have several beneficial effects in heart failure treatment. They reduce heart rate, the force of contraction, and cardiac muscle relaxation. They also slow the atrial-ventricular conduction rate and raise the threshold for arrhythmias. The concentration of β-blockers determines their effects on bronchodilation,...
336
Heart Failure Drugs: Inotropic Agents
564
Positive inotropic agents are commonly used as the first line of treatment for heart failure. One such agent is digoxin, derived from the genus Digitalis, which has been known for centuries but effectively utilized since 1785. However, these cardiac glycosides can have potentially toxic effects due to their mechanism of action, which involves inhibiting Na+/K+-ATPase and increasing contractility. Digoxin is absorbed orally and distributed in various tissues, including the CNS. It has a long...
564
Treatment for Pulmonary Arterial Hypertension: Receptor Tyrosine Kinase Inhibitors and Calcium Channel Blockers
157
Receptor tyrosine kinase inhibitors (TKIs) and calcium channel blockers (CCBs) are two critical categories of drugs employed in the treatment of pulmonary artery hypertension (PAH). PAH is a disease that causes high blood pressure in the pulmonary arteries, resulting in chest pain, fatigue, and shortness of breath.
TKIs, such as imatinib (Gleevec), are particularly effective in tackling the growth and mitogenic factors that become upregulated in PAH patients. These factors contribute to the...
TKIs, such as imatinib (Gleevec), are particularly effective in tackling the growth and mitogenic factors that become upregulated in PAH patients. These factors contribute to the...
157
Antianginal Drugs: Nitrates and β-Blockers
571
In cardiovascular health, antianginal drugs combat angina pectoris — a condition marked by chest pain owing to diminished blood flow to the heart.
Organic nitrates, such as nitroglycerin, play a pivotal role. Once metabolized, they liberate nitric oxide, a molecular marvel. Nitric oxide triggers guanylyl cyclase and augments cGMP production. This biochemical cascade orchestrates the relaxation of vascular smooth muscles, ushering in vasodilation and enhancing coronary blood flow....
Organic nitrates, such as nitroglycerin, play a pivotal role. Once metabolized, they liberate nitric oxide, a molecular marvel. Nitric oxide triggers guanylyl cyclase and augments cGMP production. This biochemical cascade orchestrates the relaxation of vascular smooth muscles, ushering in vasodilation and enhancing coronary blood flow....
571


