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具有定制直径的TiO₂纳米管用于本地药物输送系统

Sayaka Miyabe¹, Yushi Fujinaga¹, Hiroaki Tsuchiya¹

¹Division of Materials and Manufacturing Science, Graduate School of Engineering, Osaka University, Osaka, Japan.

Journal of biomedical materials research. Part B, Applied biomaterials

|July 1, 2024

概括

这项研究展示了定制的二氧化 (TiO2) 纳米管层用于局部药物递送系统 (LDDS). 调节的纳米管直径有效地抑制了最初的药物突发释放,并增强了储存能力.

科学领域:

材料科学材料科学材料科学
生物医学工程生物医学工程
纳米技术纳米技术

背景情况:

局部化药物递送系统 (LDDS) 需要精确控制药物释放动力学.
二氧化 (TiO2) 纳米管层为药物输送应用提供了一个有前途的平台.
制造方法影响TiO2纳米管结构和随后的药物释放概况.

研究的目的:

为了评估直径定制的TiO2纳米管层的药物释放行为.
研究各种化电压序列对纳米管形态和药物释放的影响.
探索模块化TiO2纳米管直径对先进LDDS的潜力.

主要方法:

制造TiO2纳米管层使用恒定电压,阶段电压和横扫电压序列的化.
纳米管内外直径和长度的表征.
从制造的TiO2纳米管结构中对药物释放动力学的体外评估.

主要成果:

成功制造了具有调节直径的TiO2纳米管层 (两直径和全形).
较小的顶部内部直径显著抑制了初始爆发药物释放和释放率.
50纳米两直径的TiO2纳米管样本表现出抑制爆发释放和高存储能力.

结论:

直径调节的TiO2纳米管层为控制LDDS中的药物释放提供了一种新的方法.
两直径的TiO2纳米管结构证明了实现抑制爆发释放和大药物储存的潜力.
这项研究开创了调制TiO2纳米管直径用于定制药物输送的应用.

关键词:

的TiO2纳米管.化是一种化.当地的药物输送系统.氧化物纳米管的使用方法

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