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基线中性粒细胞与淋巴细胞的比率作为对住院支气管切开症恶化风险反应的预测指标

Wang Chun Kwok¹, James Chung Man Ho¹, David Chi Leung Lam¹

¹Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong Special Administrative Region, China.

European clinical respiratory journal

|July 1, 2024

概括

中性粒细胞与淋巴细胞的比率 (NLR) 可以帮助预测支气管切除症恶化的住院治疗情况. 较高的NLR水平表明风险增加,为严重疾病进展提供了潜在的生物标志物.

科学领域:

肺部病理学肺部病理学
生物标志物生物标志物
炎症性疾病炎症性疾病

背景情况:

支气管切除症的特征是中性恋性炎症.
血液中性粒细胞与淋巴细胞比率 (NLR) 的预测价值对于需要住院治疗的严重支气管切除症恶化并未得到充分确立.

研究的目的:

调查NLR与由于支气管切除症恶化而需要住院治疗之间的关联.
评估NLR作为预测非囊性纤维化支气管炎严重疾病结果的潜在生物标志物.

主要方法:

一项基于登记册的回顾性队列研究,涉及香港473名非CF支气管支气管病的中国患者.
收集了2018年稳定状态患者的NLR数据,并对住院患者进行了4年 (2019-2022) 的跟踪.
使用多变量后勤回归,根据E-FACED得分,人口统计,吸烟和COPD进行调整,以分析NLR四分位数和住院之间的关联.

主要成果:

在473名患者中,有94人因支气管切除症恶化而需要住院治疗.
在最高的NLR四分位数中的患者有显著增加的住院风险 (调整后的几率比=2.02,p=0.05).

结论:

血液NLR可以作为一个有用的生物标志物来预测需要住院治疗的肺支气管病患者.
这一发现支持NLR在治疗支气管病变恶化方面的潜在临床实用性.

关键词:

支气管切除症是一种支气管切除症.生物标志物生物标志物支气管切除症恶化恶化中性粒细胞与淋巴细胞的比率.现象型现象型是一种现象型.

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