生物分子纳米结构的应用在抗血管原体治疗中
Kevin Kent Vincent Canlas1, Hansoo Park1
1School of Integrative Engineering, Chung-Ang University, Seoul, 06974, Korea.
International journal of nanomedicine
|July 1, 2024
概括
基于生物分子的纳米粒子通过克服当前治疗方法的局限性,提供了改进的抗血管生成疗法. 纳米制造的最新进展提高了它们在癌症等疾病中药物输送的实用性.
科学领域:
- 生物医学是生物医学.
- 纳米技术纳米技术
- 药物运输 药物运输 药物运输
背景情况:
- 血管新生,新血管的形成,在癌症和糖尿病等疾病中至关重要.
- 目前的抗血管生成疗法面临着交付和副作用的挑战.
- 基于生物分子的药物,包括蛋白质,脂质和寡核酸,正在成为有希望的替代品.
研究的目的:
- 审查基于生物分子的纳米颗粒 (NP) 用于抗血管生成疗法的进展.
- 要突出这些NP如何解决现有的抗血管原剂的局限性.
- 讨论工程NP在药物发现和输送系统中的潜力.
主要方法:
- 审查生物分子NP制造和工程的最新发展.
- 讨论基于脂质的脂质体和蛋白质/核酸NP用于有针对性和环境敏感的输送.
- 分析克服挑战的策略,如短的流通时间和制造困难等.
主要成果:
- 基于生物分子的NP显示出出色的生物可用性和生物活性特性.
- 工程NP显示了改善的循环时间和治疗应用的实用性.
- 纳米制造的进步显著提高了生物分子NP的实用性.
结论:
- 基于生物分子的NP代表了抗血管生成疗法的显著改善.
- 这些先进的纳米粒子提供了增强的药物输送和治疗效果.
- 在NP工程的进一步发展有望在治疗血管生成相关疾病的更广泛的应用.
相关概念视频
02:57Targeted Cancer Therapies
7.5K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.5K
01:10Mechanism of Angiogenesis
5.4K
Blood vessel formation starts early during embryonic development, around day 7. In the extraembryonic yolk sac, mesodermal precursor cells called hemangioblast proliferate and differentiate into angioblast. Angioblasts express vascular endothelial growth factor receptor 2 or VEGFR2, which binds VEGF-A, a proangiogenic factor, guiding blood vessel formation. VEGF signaling promotes angioblasts to form a blood island in the developing embryo. Angioblasts further differentiate, giving rise to...
5.4K