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产前咖啡因暴露与儿童发育之间的关联:青少年大脑认知发育 (ABCD) 研究的纵向结果

Hailey Modi^1,2, David Aa Baranger¹, Sarah E Paul¹

¹Department of Psychological and Brain Sciences, Washington University in Saint Louis, St. Louis, MO, USA.

medRxiv : the preprint server for health sciences

|July 1, 2024

概括

每日产前咖啡因暴露与更高的儿童BMI和青少年睡眠问题增加有关. 需要进一步的研究,以了解这些影响是否直接源于咖啡因或相关因素.

科学领域:

儿科健康儿科健康
发展心理学发展心理学
公共卫生公共卫生

背景情况:

怀孕期间咖啡因消费很普遍,但其对儿童发育的长期影响尚未完全理解.
现有的研究尚未全面研究产前咖啡因摄入量与青少年结果之间的关联.
这项研究解决了关于母亲咖啡因使用对儿童身体和行为健康的纵向影响的知识差距.

研究的目的:

在进入青春期的儿童中调查产前咖啡因暴露与体重指数 (BMI) 之间的关联.
检查青少年产前咖啡因摄入量与行为结果 (包括精神病理和睡眠问题) 之间的关系.
确定每日或更高水平的产前咖啡因消费是否与儿童的特定不良结果有关.

主要方法:

利用了青少年大脑和认知发展 (ABCD) 研究的纵向数据,其中包括10873名9至11岁的儿童.
护理人员报告的产前咖啡因暴露被分为四个级别,具体对比的是"任何"和"每日"暴露.
对潜在的混变量进行控制,例如家庭社会经济地位,父母心理病理,产前物质暴露和孩子自身的咖啡因使用.

主要成果:

每日产前咖啡因暴露与儿童BMI较高 (β=0.08,FDR校正 p=0.02) 有意义地相关.
在产前咖啡因暴露和儿童行为结果之间没有发现显著的关联.
暴露于每天两杯或更多杯咖啡因的儿童在产前经历了更大的睡眠问题 (β>0.92,FDR校正的p<0.04) 与暴露较低/不暴露的儿童相比.

结论:

每日产前咖啡因暴露与儿童BMI增加有关,在更高的消费水平下,在青春期有更大的睡眠问题.
这些发现表明,怀孕期间母亲的咖啡因摄入量与儿童健康不良结果之间存在潜在联系.
该研究强调需要进一步调查,以阐明这些关联是否与咖啡因有因果关系或受相关因素的影响.

关键词:

儿童发展儿童发展纵向的纵向的纵向的心理健康心理健康产前暴露于咖啡因的情况心理病理学心理病理学

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