在患有三相21的马赛克主义者中内化精神病症状
Ruth C Brown1, Allison D'Aguilar1, Quinn Hurshman2
1Virginia Commonwealth University, Department of Psychiatry.
medRxiv : the preprint server for health sciences
|July 1, 2024
概括
马赛克唐氏综合征 (mDS) 与高抑郁和焦虑率有关. 患有mDS的个体的特定恐惧与口腔细胞中的三症21水平相关,这表明需要有针对性的心理健康支持.
科学领域:
- 遗传学 是一个遗传学.
- 精神病学是一个精神病学.
- 发展生物学 发展生物学
背景情况:
- 21型三症的马赛克主义 (马赛克唐氏综合征,mDS) 与非马赛克唐氏综合征相比,表现出不同的症状严重程度.
- 患有mDS的个体的行为表型仍然不够表征,特别是在心理健康状况方面.
研究的目的:
- 调查患有mDS的个体中抑郁和焦虑症状的患病率.
- 评估这些症状与三形21细胞的百分比之间的关联.
- 评估MDS患者参与自我报告研究的能力.
主要方法:
- 一个由62名患有mDS的参与者 (年龄在12-46岁) 的样本完成了自我报告和照顾者报告的抑郁和焦虑措施.
- 基因分析确定了血液和/或口腔粘膜细胞中21型三症的百分比.
- 统计分析检查了21型三症水平和症状严重程度之间的相关性.
主要成果:
- 53%的参与者报告了临床显著的抑郁症状,76%的人报告了临床显著的焦虑症状.
- trisomy 21 的百分比和整体焦虑或抑郁的得分之间没有明确的关联.
- 在口腔样本中三体细胞的百分比和自我报告的特定恐惧之间观察到正相关性 (r = .43,p = .007).
结论:
- 患有mDS的个体有很高的抑郁和焦虑症状,需要定期进行心理健康评估.
- 三体细胞的百分比可能会影响特定的焦虑症状,例如特定的恐惧.
- 患有mDS的个体能够参与研究,支持将其纳入临床试验和研究.
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