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Updated: Jun 22, 2025

In Vitro Modeling of Down Syndrome Neurogenesis Using Human-Induced Pluripotent Stem Cells
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抑制JAK可以降低唐氏综合征的自身免疫负担

Angela L Rachubinski1,2, Elizabeth Wallace3, Emily Gurnee3

  • 1Linda Crnic Institute for Down Syndrome, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.

medRxiv : the preprint server for health sciences
|July 1, 2024
PubMed
概括

唐氏综合症 (DS) 涉及免疫失调和自身免疫. 一种JAK抑制剂托法西替尼 (tofacitinib) 在第二阶段试验中显示出安全性和有效性,减少了DS患者的皮肤病理和病原性自身抗体.

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