使用普罗普拉诺洛尔的偏头痛患者中风风险降低:来自两个大规模现实世界数据分析的证据
Eugene Jeong1, Mulubrhan F Mogos2, You Chen1,3
1Department of Biomedical Informatics, School of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America.
medRxiv : the preprint server for health sciences
|July 1, 2024
概括
在女性偏头痛患者,尤其是那些没有光环的偏头痛患者中,普罗普拉诺显著降低了中风风险. 这种β-阻断剂在特定高风险人群中可能有助于预防中风.
科学领域:
- 神经学 神经学
- 心血管医学 心血管医学
- 药理学 药理学是指药理学的学科.
背景情况:
- 兰醇是一种非选择性β-阻断剂,广泛用于偏头痛预防.
- 罗对偏头痛患者中风风险的影响尚未得到充分证实.
- 关于普拉诺洛尔对这一群体中风风险的影响存在争议.
研究的目的:
- 研究在偏头痛患者中使用普拉诺洛尔与中风风险之间的关联.
- 为了比较偏头痛患者的中风风险,有和没有记录的propranolol使用.
- 根据性别和偏头痛亚型分层分析.
主要方法:
- 一个回顾性病例控制研究,使用两个大型数据集 (VUMC和我们所有人) 的电子健康记录.
- 使用ICHD-3标准识别的偏头痛患者;病例中患有中风后偏头痛诊断,对照组没有.
- 使用后勤回归和Cox比例危险模型来评估与甲醇使用相关的中风风险,以混因素进行调整.
主要成果:
- 在女性偏头痛患者中,罗的使用与明显降低中风风险有关 (VUMC:OR=0.52;All of Us:OR=0.39).
- 这种保护作用在缺血性中风和没有光环的偏头痛 (MO) 的女性中更为明显.
- 纵向分析显示,在10年的时间里,在接受普拉诺洛尔治疗的女性偏头痛患者中,中风发生率始终较低.
结论:
- 在没有光环的女性偏头痛患者中,propranolol与中风风险显著降低有关,特别是缺血性中风.
- 研究结果表明,在特定的偏头痛高风险人群中,propranolol可能是预防中风的有益药物.
- 进一步的研究可能会阐明正确的机制和最优的使用propranolol中风风险降低偏头痛.
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