制定研究议程,以检查高认知脱综合征症状的早期风险,使用ABCD队列数据
Kelsey K Wiggs1, Taryn E Cook2, Isha Lodhawala1
1Cincinnati Children's Hospital Medical Center.
Research square
|July 1, 2024
概括
早期的生命风险,如意外怀孕和产前物质暴露,与儿童的认知失调综合征 (CDS) 有关. 这项研究突出了未来对CDS起源研究的关键因素.
科学领域:
- 儿童心理学 儿童心理学
- 发育神经科学的发展神经科学.
- 儿科卫生保健 儿科卫生保健
背景情况:
- 有限的研究存在于认知失调综合征 (CDS) 的早期生命风险因素.
- 现有的文献集中在诸如ADHD之类的并发疾病上.
- 这项研究通过检查CDS的早期生命风险因素来解决这一差距.
研究的目的:
- 估计早期生命风险因素和CDS症状之间的关联.
- 分析来自美国儿童大型代表样本的数据.
- 识别潜在的CDS早期指标.
主要方法:
- 青少年大脑认知发展 (ABCD) 研究数据的二次分析 (N=8,096).
- 利用父母报告的风险因素 (父母,产前,分娩,里程碑) 的发展史.
- 使用儿童行为检查清单评估CDS症状,对高分数进行二分化 (T>70).
主要成果:
- 在CDS和家长风险因素 (例如,意外怀孕,青少年父母) 之间发现了显著的关联.
- 产前因素包括父母的疾病,并发症和物质暴露与更高的CDS几率有关.
- 延迟的运动和语言里程碑也与增加的CDS症状相关.
结论:
- 多种早期的风险因素与9-10岁的CDS几率增加有关.
- 由于研究设计,无法确定因果关系.
- 建议进行进一步的研究,重点关注影响胎儿发育的因素 (生长,营养素,氧气).
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