食氨基酸促进类似于葡萄糖的激素的释放,从而在脂肪组织中产生新的波

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Li He¹, Muhammad Ahmad², Shang Wu¹

¹University of Science and Technology of China.

Research square

|July 1, 2024

概括

饮食中的氨基酸触发阿迪波基尼特激素 (AKH) 释放,激发在的脂肪组织中的新型细胞间波 (ICWs),通过独立于间隙结路径促进脂质代谢.

科学领域:

代谢调节代谢调节代谢调节
信号传递的.
内分泌学在内分泌学.

背景情况:

细胞质Ca2+对于代谢调节至关重要,影响诸如糖解和脂解之类的过程.
细胞间波 (ICWs) 协调多细胞反应,但它们在体内调节的理解甚微.
脂肪组织在能量恒温中发挥着中心作用,并与代谢疾病有关.

研究的目的:

为了研究Drosophila脂肪组织中ICWs的实时动态.
确定昆虫体脂肪中的Ca2+信号传递和ICW的关键调节者.
阐明ICWs影响脂解和代谢反应的机制.

主要方法:

在器官培养和自由行为Drosophila中的Ca2+动态的体内成像.
使用遗传学和药理学方法识别信号分子.
对激素分泌,细胞外扩散和细胞间通信通路的分析.

主要成果:

基动力激素 (AKH) 被确定为Drosophila脂肪组织中Ca2+活性的主要驱动因素.
AKH在幼虫脂肪中刺激间隙结独立的ICW,以促进脂解.
成年人体脂肪表现出差距连接依赖的ICWs,表明阶段特定的调节.
饮食中的氨基酸激活AKH产生神经分泌细胞 (APC),增加AKH分泌.

结论:

饮食中的氨基酸调节AKH的释放,影响脂肪组织的功能.
新的独立于间隙连接的ICWs在幼虫脂肪组织中受到AKH的刺激.
这项研究揭示了代谢调节中细胞间信号的特定阶段机制.

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