尼尔马特里尔维尔/里托纳维尔治疗后的COVID-19临床复苏
Daniel Camp1, Matthew Caputo1, Fabiola Moreno Echevarria1
1Northwestern University.
Research square
|July 1, 2024
概括
针对COVID-19的涅玛特里尔维尔/里托纳维尔 (NM/r) 可能会在6%的患者中引起反弹症状,通常是轻微的,并迅速消失. 这项现实世界的研究发现反弹比以前认为的更常见.
科学领域:
- 传染性疾病 传染性疾病
- 病毒学 病毒学
- 临床医学 临床医学
背景情况:
- 尼尔马特里尔维尔/里托纳维尔 (NM/r) 是一种口服抗病毒药物,用于治疗轻度至中度的COVID-19.
- 报告了临床反弹综合征,治疗后症状复发的特征.
- 关于NM/r反弹频率,促成因素和日常护理结果的信息有限.
研究的目的:
- 在现实环境中确定NM/r治疗后COVID-19临床反弹的频率.
- 为了确定与COVID-19反弹相关的潜在人口和临床因素.
- 评估经历COVID-19反弹的患者的临床结果.
主要方法:
- 对2022年1月至6月用NM/r治疗的患者电子病历的回顾性审查.
- COVID-19临床反弹的定义:症状改善,随后在5天的NM/r疗程后30天内复发或恶化.
- 对人口统计数据,并发病症,疫苗接种情况和之前的SARS-CoV-2感染情况的分析.
主要成果:
- 总共研究了268名成年人;6.0% (16名患者) 经历了COVID-19临床反弹.
- 从NM/r开始到反弹的中位时间为11天.
- 虽然在统计学上不显著,但在复发患者中比例较高的因素包括女性性别,黑人种族,并发症和缺乏先前感染. 只有一个病人需要住院治疗.
结论:
- 在NM/r治疗后的COVID-19临床反弹在现实实践中比以前建议的更频繁.
- 反弹病例通常是轻微的,并与有利的临床结果相关.
- 进一步的研究可能会澄清导致因素,并优化NM/r治疗患者的管理策略.
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