用实证万科米辛 (STOP-Vanc) 优化肺炎治疗的抽样检测:一项随机对照试验的研究协议
Jeffrey A Freiberg1,2, Justin K Siemann3, Edward T Qian4,5
1Division of Infectious Diseases, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
这项随机试验研究了使用耐甲素黄金葡萄球菌 (MRSA) 鼻抽样PCR测试来指导肺炎患者使用万科米辛. 该研究旨在安全地减少抗生素暴露,并改善重症监护病房的临床结果.
科学领域:
- 传染性疾病 传染性疾病
- 临床试验 临床试验
- 抗微生物药物管理委员会
背景情况:
- 尽管罕见的MRSA参与,但万科米辛通常在经验上用于社区获得的肺炎 (CAP).
- 通过鼻子擦拭物测试耐甲基西林黄金葡萄球菌 (MRSA) 殖民试验是一种拟议的抗菌管理干预措施.
- 之前的观察性研究表明,在MRSA测试中减少了范科米辛的使用,但随机对照试验 (RCT) 数据缺乏.
研究的目的:
- 评估MRSA鼻PCR测试的有效性,以指导怀疑CAP的万科米辛降级.
- 提供第一个关于使用MRSA PCR测试用于抗生素管理的RCT数据.
- 评估MRSA PCR测试和管理指南对ICU环境中的临床结果的影响.
主要方法:
- STOP-Vanc试验是一个务实,前性,单中心,非盲目的RCT,用于在ICU接受万科米辛的成年患者,怀疑患有CAP.
- 患者被随机分配1:1接受MRSA鼻PCR测试加上常规护理或仅接受常规护理.
- 主要结局是入学后七天内活着的无万科米辛小时.
主要成果:
- 本部分应在研究结果可用后填写.
结论:
- 这项试验将提供关键的RCT证据,以证明MRSA鼻抽样PCR测试在抗生素降级中的作用.
- 调查结果将为在重症监护机构内的CAP管理中对抗微生物药物管理实践和万科胺的利用提供信息.
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