在没有意识的情况下理解意识发作:文献综述
Emilie Groulx-Boivin1,2, Tasha Bouchet3, Kenneth A Myers1,2,4
1Department of Neurology and Neurosurgery, Montreal Children's Hospital, McGill University, Montreal, Quebec, Canada.
Neuropsychiatric disease and treatment
|July 1, 2024
概括
缺席发作会导致暂时的意识缺陷,但它们的确切大脑机制仍然不清楚. 本综述使用各种神经成像技术探索了在缺席发作期间意识受损的神经相关性.
科学领域:
- 神经科学是一个神经科学.
- 的研究研究.
- 认知神经学 认知神经学
背景情况:
- 缺席发作与行为停滞和可变意识损伤有关.
- 认知缺陷的潜在病理生理学和机制尚未完全理解.
- 建议的机制包括皮质失活和默认模式网络中断.
研究的目的:
- 审查当前关于在缺席发作中意识受损神经相关的知识.
- 综合来自各种神经成像和动物模型研究的发现.
主要方法:
- 对现有的文献进行审查.
- 分析使用电脑电图 (EEG) 的研究.
- 检查功能磁共振成像 (fMRI) 数据的检查.
- 包括磁脑图 (MEG) 和正子发射断层扫描 (PET) 的发现.
- 考虑单光子发射计算机断层扫描 (SPECT) 结果.
- 从缺席的动物模型中整合证据.
主要成果:
- 有证据表明复杂的神经网络参与,而不是简单的停用.
- 改变大脑活动的特定模式与发作严重程度和认知障碍相关.
- 在thalamocortical和corticocortical网络中持续观察到干扰.
结论:
- 了解在缺席中意识损失的神经基础对于开发向疗法至关重要.
- 需要进一步研究整合多式联络神经成像来充分阐明这些机制.
- 本综述强调了关键的发现,并确定了关于缺席病理生理学的当前知识的差距.
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