与生物疗法相关的密码球菌病:叙述性审查
Xin Li1,2, Olivier Paccoud1, Koon-Ho Chan3
1Department of Infectious Diseases and Tropical Medicine, Université Paris Cité, Necker-Enfants Malades University Hospital, Assistance Publique-Hôpitaux de Paris, IHU Imagine, Paris, France.
Open forum infectious diseases
|July 1, 2024
概括
服用生物药物的患者,特别是那些向Th1/巨细胞通路的患者,面临着加密球菌病的风险增加. 警和风险分层对于管理这种机会性真菌感染至关重要.
科学领域:
- 菌类学 菌类学是指菌类学.
- 免疫学 免疫学 免疫学
- 传染性疾病 传染性疾病
背景情况:
- 加密球菌是一种机会性真菌病原体,会引起严重的感染,特别是在免疫力低下的人群中.
- 生物药物广泛用于瘤,自身免疫性疾病和移植拒绝,可能会损害免疫防御.
- 这增加了对机会性感染的易感性,例如加密球菌病.
研究的目的:
- 审查加密球菌病与各种生物疗法之间的关联.
- 要突出感染风险,临床表现和使用生物制剂的患者的结果.
- 告知临床医生关于这个人群中的加密球菌病风险分层.
主要方法:
- 综合文献综述. 这是一个全面的文献综述.
- 对接受生物药物治疗的患者加密球菌病的研究进行分析.
- 综合有关风险因素,临床表现和结果的数据.
主要成果:
- 针对Th1/巨细胞激活通路的生物药物 (例如TNFα对抗剂,BTK抑制剂,fingolimod,JAK/STAT抑制剂,抗CD52抗体) 与加密球菌病的风险增加有关.
- 临床表现和结果各不相同,中枢神经系统的参与是常见的.
- 同时使用免疫抑制剂,特别是皮质类固醇,进一步增加风险.
结论:
- 临床医生必须在接受特定生物制剂治疗的患者中对加密球菌病保持警.
- 风险分层应考虑生物类型,潜在疾病,年龄和同时接受的免疫抑制疗法.
- 早期识别和管理对于改善风险患者的治疗结果至关重要.
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