炎症性肠病患者的急性损伤:全国性的比较分析
Manish K Saha1, Susan L Hogan1, Ronald J Falk1
1Division of Nephrology and Hypertension, University of North Carolina at Chapel Hill, Chapel Hill, NC.
Kidney medicine
|July 1, 2024
概括
与患有原血管疾病或一般人群相比,患有炎症性肠病 (IBD) 的患者患急性损伤 (AKI) 的风险更高. 在IBD患者中,应密切监测脏健康状况.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 胃肠病学 胃肠病学
- 流行病学 流行病学
背景情况:
- 炎症性肠病 (IBD) 与各种肠外表现有关.
- 在IBD患者中,脏参与是公认的,但在美国缺乏基于人口的流行数据.
- 急性损伤 (AKI) 是住院患者的一个重大问题.
研究的目的:
- 为了比较AKI在IBD住院患者中的频率和风险,与原血管疾病患者和一般人群相比.
- 估计IBD患者中需要透析的AKI和AKI的患病率.
- 在IBD管理中为病提供临床考虑的信息.
主要方法:
- 基于人口的回顾性队列研究,使用医疗保健成本和利用项目全国性住院患者样本数据库.
- 包括超过570万次住院治疗,包括IBD,原血管疾病的特定队列,以及一般人口的比较.
- 分析AKI和AKI需要透析结果,使用回归模型,用于共变量平衡治疗权重的逆概率.
主要成果:
- 患有IBD的住院病例显示,与原血管疾病 (15%) 和一般人口 (12.2%) 相比,AKI (13%) 的发病率更高.
- 调整后的分析显示,IBD住院患者中AKI的几率明显高于两组对照组 (OR分别为1.32和1.27).
- 与原血管疾病 (OR 1.59) 和普通人群 (OR 1.45) 相比,IBD住院患者患有需要透析的AKI的几率也更高.
结论:
- 在涉及IBD的住院治疗中,AKI的患病率和风险增加.
- 患有IBD的患者更有可能患上AKI,包括需要透析.
- 同时存在的脏疾病应该是诊断为IBD的患者的关键考虑因素.
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