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Updated: Jun 22, 2025

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分子洞察HIV-TAT蛋白对粉样蛋白β的作用

Asis K Jana1, Recep Keskin2, Fatih Yaşar2

  • 1Department of Microbiology and Biotechnology, Sister Nivedita University, Kolkata 700156, India.

ACS omega
|July 1, 2024
PubMed
概括

艾滋病毒TAT蛋白通过改变Aβ结构和稳定纤维来加速粉样蛋白β (Aβ) 斑块的形成. 这种分子洞察力可能会解释艾滋病毒患者中阿尔茨海默病的联系.

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Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining,...
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