在口腔之外:通过口腔症状发现非分泌性多发性骨髓瘤
Pedro Henrique Chaves Isaias1, Fábio Wildson Gurgel Costa1, Pedro Henrique Gonçalves Holanda Amorim2
1Department of Dental Clinic, Postgraduate Program in Dentistry, Federal University of Ceará, Fortaleza, Ceará, Brazil.
Imaging science in dentistry
|July 1, 2024
概括
非分泌性多发性骨髓瘤 (NSMM) 是一种罕见的血细胞癌,可以表现为口腔症状,如下疼痛. 早期的牙科检测对于管理这种情况至关重要,正如一个患者的病例研究所示,该患者实现了缓解.
科学领域:
- 在瘤学瘤学.
- 血液学 血液学 血液学
- 口腔医学是指口腔医学.
背景情况:
- 非分泌性多发性骨髓瘤 (NSMM) 是一种罕见的血细胞恶性瘤,缺乏可检测的单克隆M蛋白.
- 口腔表现,虽然不常见,但可以是NSMM的初始表现.
研究的目的:
- 报告一个出现下病变的NSMM病例.
- 突出牙科专业人员在早期NSMM检测中的作用.
主要方法:
- 一名57岁的女性患者出现了下下疼痛和骨解损伤.
- 活检证实了一种恶性血细胞瘤 (对卡帕阳性,CD138,MUM1,CD79a;对兰巴阴性,CD20).
- 标准骨髓瘤查测试 (血清/尿液电泳,自由光链检测) 呈阴性,证实了NSMM诊断.
主要成果:
- 患者表现出下骨解损伤和根再吸收.
- 组织病理学和免疫类型鉴定证实了血细胞瘤.
- 尽管骨髓瘤的血清学标记是负的,但NSMM的诊断确立了.
结论:
- NSMM可以呈现出显著的口腔病理,包括下病变.
- 牙医在早期识别NSMM中发挥着至关重要的作用,使得迅速治疗成为可能.
- 跨学科的合作对于管理罕见的血细胞瘤是必不可少的.
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