[复发性自发性流产的晚产期妇女的幽默免疫异常:单一中心研究]
Guohua Li1, Xujing Deng1, Shihua Bao1
1( 200092) Department of Reproductive Immunity of Shanghai First Maternity and Infant Hospital, Shanghai 200092, China.
概括
晚年母亲的年龄并没有改变反复自发流产 (RSA) 的女性的幽默免疫力. 这项研究发现,老年和年轻RSA患者之间的自身抗体患病率没有显著差异.
科学领域:
- 生殖免疫学 生殖免疫学
- 孕产妇和胎儿医学 孕产妇和胎儿医学
背景情况:
- 经常性自发流产 (RSA) 影响所有年龄段的女性.
- 幽默免疫在怀孕结果中起着重要作用.
- 晚年母亲对与RSA相关的幽默免疫的影响需要进一步调查.
研究的目的:
- 为了比较晚产妇年龄女性 (35-45岁) 与低产妇年龄女性 (20-34岁) 的幽默免疫力.
- 在不同孕产妇年龄组中识别与RSA相关的特定自身抗体.
主要方法:
- 对4009名RSA妇女进行了回顾性研究.
- 测试多种自身抗体,包括抗脂抗体 (aPLs),抗核抗体 (ANA) 和甲状腺自身免疫性 (TAI).
- 多变量逻辑回归控制BMI,以前的活产史和堕胎数量.
主要成果:
- 年龄组之间对自身免疫性疾病或大多数自身抗体 (aPLs, ANA, ENA, dsDNA, ssDNA, AAA, TAI) 的患病率没有统计差异.
- 在晚产妇年龄组 (1.6%) 与低产妇年龄组 (2.7%) 相比,观察到较低的狼抗凝剂 (LA) 阳性率.
结论:
- 在患有RSA的晚产阶段和低产阶段妇女之间,幽默免疫特征是相似的.
- 观察到的狼抗凝剂患病率的差异需要进一步研究其对RSA的临床意义.
相关概念视频
Development of Immunocompetence
301
The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
301
Humoral Immune Responses
72.5K
Overview
72.5K
Transcytosis of IgG
2.7K
Transcytosis is the process in which molecules are internalized by endocytosis, transported across the cell, and released through exocytosis from the opposite end of the cell. Molecules such as insulin, immunoglobulins, and certain nutrients are transferred through the recycling endosomes by recycling and transcytosis.
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...
2.7K
Meiosis vs. Mitosis
55.0K
Cell division is necessary for growth and reproduction in organisms. Mitosis aids cell growth and development by dividing somatic cells. In contrast, meiosis causes the division of germ cells and plays an essential role in sexual reproduction. Due to their unique functional requirements, mitosis and meiosis differ from each other in multiple aspects.
Before the start of mitosis and meiosis I, the cell synthesizes DNA, resulting in two homologous copies of each chromosome. DNA synthesis is...
Before the start of mitosis and meiosis I, the cell synthesizes DNA, resulting in two homologous copies of each chromosome. DNA synthesis is...
55.0K
Immunological Memory
585
Immunological memory, a pivotal pillar of the adaptive immune system, is responsible for the body's ability to remember and respond more swiftly and effectively to previously encountered pathogens. This remarkable feature is what makes vaccines so effective in preventing diseases.
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
585
Oogenesis
63.6K
In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...
63.6K


