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[假设的酒精消费干预和肝硬化症:大型队列的长度研究]
Ning Zhang1, Yuan Zhang1, Jun Wei1
1/ （ 610041） Department of Epidemiology and Biostatistics, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu 610041, China.
概括
在西方人群中,增加酒精消费会增加肝硬化风险. 与其他饮料相比,转换为红葡萄酒可能会降低这种风险,为公共卫生政策提供潜在的指导.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 非酒精性脂肪肝 (NAFLD) 和与酒精有关的脂肪肝 (ALD) 是普遍存在的慢性肝病.
- 肝肥胖症是NAFLD和ALD的早期症状,与过度饮酒有关,但适度饮酒的影响仍在争论中.
- 现有的研究往往使用一次性酒精摄入量评估,未能捕捉生活方式的变化和告知政策.
研究的目的:
- 用纵向数据估计假设的酒精消费变化对肝肥胖症的影响.
- 为公共卫生政策和临床指南提供有关酒精消费和肝脏健康的信息.
- 调查不同类型的酒精饮料对肝硬化症的影响.
主要方法:
- 一项对12687名英国生物库参与者的纵向研究,包括基线和重复调查.
- 脂肪肝指数 (FLI) 从甘油三,GGT,BMI和腰围计算出来,作为结果使用.
- 参数g公式应用于对酒精量和饮料类型 (红葡萄酒,酒,烈酒) 的假设干预模型.
主要成果:
- 与持续水平相比,增加酒精消费干预措施与更高的FLI有关.
- 从不饮酒过渡到中度或重度饮酒增加了FLI (比例分别为1.027和1.075).
- 转换为红葡萄酒与其他饮料 (例如烈酒) 的持续消费相比,与较低的FLI有关.
结论:
- 增加酒精摄入量的干预措施在西方人群中增加了肝硬化风险.
- 结果可以指导未来的实践指南和有关酒精消费的健康政策.
- 如果完全戒酒是不可能的,红葡萄酒可能是比其他酒精饮料更不有害的选择.
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