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系统性红斑狼患者的卵巢功能:发病,药物应用和潜在的治疗方法

Min Xu¹, Li-Li Tian¹, Xiao-Liu Li¹

¹Department of Rheumatology and Immunology, Nanjing Drum Tower Hospital, Clinical College of Nanjing University of Chinese Medicine, Nanjing 210008, Jiangsu Province, China.

World journal of experimental medicine

|July 1, 2024

概括

系统性红斑狼 (SLE) 治疗可以损害女性的卵巢功能. 本综述涵盖了卵巢损伤,药物效应和提高SLE妇女想要后代的生育能力的策略.

科学领域:

生殖免疫学生殖免疫学
自身免疫性疾病的研究.
药理学药理学是指药理学的学科.

背景情况:

系统性红斑狼 (SLE) 是一种慢性自身免疫性疾病,影响多个器官,主要发生在生育年龄的妇女身上.
目前用于SLE的治疗方法,包括葡萄糖皮质类药物和免疫抑制剂,与显著的副作用有关.
卵巢功能障碍是SLE治疗妇女的一个已知的并发症,影响生育能力和生殖健康.

研究的目的:

审查当前对系统性红斑狼的卵巢损伤的理解.
分析常见的SLE治疗对卵巢功能的影响.
探索希望怀孕的SLE妇女的卵巢功能保护或改善的策略.

主要方法:

关于SLE,卵巢功能和生殖健康的最新研究的文献综述.
对免疫抑制剂和葡萄糖皮质类药物对女性生殖系统的药理作用的分析.
在SLE患者的卵巢保护新兴治疗策略的综合.

主要成果:

在SLE治疗和阴性卵巢损伤之间确立了联系.
确定了与卵巢功能障碍风险增加相关的特定药物和剂量.
突出了潜在的干预措施和支持性疗法,以减轻治疗引起的卵巢损伤.

结论:

卵巢功能障碍是SLE接受治疗的妇女的一个关键问题.
需要采取全面的方法,以平衡SLE管理与生殖潜力的保护.
对节育策略的进一步研究对于改善想要孩子的SLE患者的治疗结果至关重要.

关键词:

自身免疫性疾病是一种自身免疫性疾病.生育能力生育能力生育能力介质细胞干细胞介质细胞干细胞卵巢功能不良卵巢功能不良卵巢储备卵巢储备卵巢储备系统性红血性狼 (Systemic lupus erythematosusus) 是一种全身性狼.

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