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肝移植中的寒冷缺血时间:概述

Manuela Cesaretti^1,2, Alessandro Izzo¹, Roberta Anna Pellegrino¹

¹Department of HPB and Liver Transplantation, Brotzu Hospital, Cagliari 09122, Italy.

World journal of hepatology

|July 1, 2024

概括

肝移植中的冷缺血时间 (CIT),定义为移植交叉紧和再输血之间的时间,是关键的风险因素. 本审查审查了CIT组件和保存策略,以改善移植的生存.

科学领域:

移植免疫学移植免疫学
器官的保存器官的保存
外科手术的危险因素

背景情况:

静态冷藏是肝移植保存的标准.
寒冷缺血时间 (CIT) 是一个关键的与供体相关的风险因素,影响了移植和受体的生存.
越来越多地使用边缘肝移植,需要分析CIT因素.

研究的目的:

在肝移植中定义冷缺血时间 (CIT).
分析CIT的多因素组成部分.
探索新的器官保存策略,以减轻缺血性损伤.

主要方法:

审查关于肝移植和器官保存的现有文献.
作为CIT组件,分析了供体肝切除术时间,传输时间和受体手术时间.
探索植入物保护策略的最新进展.

主要成果:

CIT是一个复杂的指标,受多个手术阶段的影响.
边缘肝移植特别容易受到长期的CIT.
新兴的策略旨在优化每个CIT时间并减少缺血性损伤.

结论:

了解和尽量减少CIT对于成功的肝移植至关重要.
创新的保存技术对于改善边缘移植的结果至关重要.
对CIT缓解策略的进一步研究可以提高移植物和受体的生存率.

关键词:

寒冷缺血时间在心脏病死亡后的捐赠.肝脏移植肝脏移植机器 perfusion perfusion 机器输液,可以通过输液进行输液.器官捐赠器官捐赠器官捐赠器官捐赠器官捐赠器官捐赠器官捐赠器官捐赠器官捐赠器官捐赠器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐赠器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器热性缺血时间

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