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与甲状腺自身免疫相关的胚胎发育潜力的损害,在甲状腺不育妇女中,甲状腺不育妇女的卵巢储备减少
Yongjie Zhang1, Yuchao Zhang1, Zhuolun Su1
1Reproductive Center, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Frontiers in endocrinology
|July 1, 2024
概括
甲状腺自身免疫 (TAI) 与卵子数量较少和卵巢储备减少 (DOR) 的妇女的胚胎质量较差有关. 较高的抗体水平与减少的卵细胞产量和胚胎质量相关,这表明对TAI进行查是有益的.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 免疫学 免疫学 免疫学
- 不孕症研究 不孕症研究
背景情况:
- 卵巢储备减少 (DOR) 影响生育能力,甲状腺自身免疫 (TAI) 是一个潜在的促成因素.
- 了解TAI对卵细胞检索和胚胎发育的影响对于管理不孕症至关重要.
研究的目的:
- 调查甲状腺自身免疫 (TAI) 与卵巢反应和胚胎质量的关键指标之间的联系.
- 为了确定TAI和特定抗体水平 (TPOAb,TgAb) 是否会影响DOR患者的卵细胞数量 (NOR),受精率 (FR) 和胚胎质量 (EQ).
主要方法:
- 对1,172名患有不孕症和DOR进行卵细胞检索的甲状腺女性 (20-40岁) 进行了回顾性队列研究.
- 通过血清铁氧化酶抗体 (TPOAb) 或铁球蛋白抗体 (TgAb) 水平升高而诊断出TAI.
- 一般化的线性模型和逻辑回归用于分析TAI,抗体度和生殖结果之间的关联.
主要成果:
- 与没有TAI的女性相比,TAI的女性显示出明显较低的NOR和较差的EQ (P<0.001).
- 升高的TPOAb和TgAb度与NOR和高质量和可用的胚胎数量 (P <0.05) 相反相关.
- 较高的TPOAb水平降低了达到高NOR的可能性 (aOR:0.56;P = 0.007).
结论:
- TAI和TPOAb/TgAb水平升高与不孕症和DOR妇女的NOR和EQ降低有关.
- 这些发现支持在这个患者群体中对TAI进行系统的查和治疗.
- 进一步的研究可能会阐明将TAI与卵巢反应受损联系起来的特定机制.
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