血清Klotho与美国心血管患者全因死亡率之间的U形关联:前性队列研究
Shasha Liu1, Zhanfang Zhu2, Kai Yu3
1Department of Cardiology, Shaanxi Provincial People's Hospital, Xi'an, China.
Frontiers in endocrinology
|July 1, 2024
概括
血清Klotho水平显示出U形的关联与心血管疾病 (CVD) 患者的全因死亡率. 更高的克洛托水平可能会降低死亡率,但非常高的水平可能会增加风险,这需要进一步的研究.
科学领域:
- 心脏病学 心脏病学
- 内分泌学 在内分泌学.
- 老年学是一门学科.
背景情况:
- 血清克洛托与降低心血管疾病 (CVD) 风险有关.
- 有限的研究存在于血清Klotho与心血管疾病患者的死亡率的关联.
研究的目的:
- 为了研究血清Klotho水平和心血管疾病患者的死亡率之间的关系.
- 探索血清Klotho与心血管疾病患者死亡率的剂量反应和亚组关联.
主要方法:
- 利用国家健康和营养检查调查 (NHANES) 数据 (2007-2016) 与国家死亡指数相关联.
- 采用考克斯回归,卡普兰-梅尔曲线和受限立方线来分析血清克洛托和死亡率.
- 进行了子组分析,以检查不同患者群体中的关联.
主要成果:
- 在1905年心血管疾病患者的血清Klotho水平和全因死亡率之间观察到U形关系.
- 较高的血清Klotho水平与较低的全因死亡率有关,但非常高的水平表明风险增加的趋势.
- 血清Klotho和心血管死亡率之间没有发现显著的关联;高血压亚组在最高Klotho水平下显示死亡风险增加.
结论:
- 血清Klotho水平与心血管疾病患者的全因死亡率呈现出U形的关联.
- 复杂的关系表明中等水平的潜在保护作用和非常高水平的潜在风险.
- 需要进一步的研究来阐明驱动这种U形关联的潜在机制.
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