接种COVID-19疫苗的类型不会影响不育夫妇的生殖功能和怀孕结果
Shiming Wang1, Ningning Wang1, Guidong Yao1
1Reproductive Medical Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Frontiers in endocrinology
|July 1, 2024
概括
疫苗类型不会对体外受精 (IVF) 的结果产生负面影响. 这项研究发现,在接受试管婴儿的接种疫苗的人群中,对卵巢刺激,胚胎发育或精液参数没有任何不良影响.
科学领域:
- 生殖医学 生殖医学
- 疫苗学 疫苗学 疫苗学
- 在体外受精过程中受精.
背景情况:
- 关于各种疫苗类型对体外受精 (IVF) 结果的影响的研究有限.
- 了解疫苗接种对男性和女性生殖功能的潜在不良影响至关重要.
研究的目的:
- 研究不同类型的疫苗对接受试管婴儿的个体生殖功能和临床怀孕率的影响.
- 评估疫苗接种状态对卵巢刺激,胚胎发育和精液参数的影响.
主要方法:
- 对6455个新鲜胚胎移植周期的回顾性研究.
- 从2021年5月到2022年10月在州大学第一附属医院收集的数据.
- 主要结局:临床妊娠率 (CPR);次要结局:卵细胞检索,受精率,胚胎发育和精液参数.
主要成果:
- 在不同疫苗组的卵巢刺激指标 (例如, Gn 天,子宫内膜厚度) 或胚胎发育率 (2PN,胚胎囊形成) 中没有观察到统计学意义上的差异.
- 精液参数 (体积,密度,运动性,DNA碎片化) 和人口统计数据 (年龄,BMI) 在两组之间没有显著差异.
- 多变量回归分析证实,疫苗类型和疫苗接种状态都没有显著影响临床怀孕率.
结论:
- 目前的疫苗类型似乎不会对接受试管婴儿的人的卵巢刺激,胚胎发育或精液参数产生不利影响.
- 不孕夫妇的疫苗接种状况没有证明对临床妊娠结果产生负面影响.
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