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在患有自身免疫性类风湿性疾病的患者中,Covishield疫苗的免疫性
Vikas Gupta1, Vikram Kumar Gupta2, Navjot Kaur Bajwa3
1Department of Clinical Immunology and Rheumatology, DMC and H, Ludhiana, Punjab, India.
与健康个体相比,患有自身免疫性风湿性疾病 (AIRD) 的患者对Covishield疫苗的抗体反应类似. 用普得尼索隆或甲铁酸治疗没有显著影响免疫性,这表明Covishield对AIRD患者有效.
科学领域:
- 免疫学 免疫学 免疫学
- 疫苗学 疫苗学 疫苗学
- 类风湿病学 类风湿病学
背景情况:
- 由于COVID-19的流行,需要大规模的疫苗接种工作.
- 接受免疫抑制剂的自身免疫性类风湿性疾病 (AIRD) 患者是接种疫苗的优先组.
- 有限的数据存在于AIRD患者的COVID-19疫苗疗效.
研究的目的:
- 评估Covishield疫苗在患有AIRDs的患者中的免疫性.
- 为了比较AIRD患者的抗体标位和疫苗接种后的健康对照.
主要方法:
- 一项前性队列研究包括50名AIRD患者和52名健康对照.
- 参与者接受了两剂Covishield疫苗.
- 在第二剂后28天测量了抗SARS-CoV-2尖端蛋白受体结合域抗体.
主要成果:
- 在AIRD患者和健康对照人群之间没有观察到抗体标位的显著差异.
- 普雷迪尼索隆和甲状腺素治疗没有显著影响抗体标位.
- 与对照组相比,接受mycophenolate mofetil的患者表现出抗体标位在统计学上显著下降.
结论:
- 接种Covishield疫苗在AIRD患者和健康人群中显示出可比的免疫性.
- 印度的AIRD患者可以安全地用Covishield接种疫苗,而不必担心有效性降低.
- 对于服用特定免疫抑制剂的患者,如mycophenolate mofetil,可能需要进一步的研究.
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