仔细观察周期值,临床特征和生物标志物之间的联系:一项针对COVID-19患者的观察性研究
Sriram Kannuri1, Rajashri Patil1, Sahjid Mukhida1
1Department of Microbiology, Dr. D. Y. Patil Medical College, Hospital and Research Centre, Dr. D. Y. Patil Vidyapeeth, Pimpri, Pune, Maharashtra, India.
Journal of family medicine and primary care
|July 1, 2024
概括
与严重急性呼吸综合征相关的冠状病毒2 (SARS-CoV-2) 检测中的周期值 (Ct) 不是冠状病毒疾病 (COVID) 严重程度的可靠指标. 生物标志物更有效地预测患者的预后.
科学领域:
- 病毒学 病毒学
- 临床诊断 临床诊断 临床诊断
- 公共卫生 公共卫生
背景情况:
- 严重急性呼吸系统综合征相关的冠状病毒2 (SARS-CoV-2) 导致冠状病毒疾病 (COVID),症状在暴露后2-3天出现.
- 聚合酶连锁反应 (PCR) 是主要的病毒检测方法,因为它的高灵敏度和特异性.
- 关于COVID-19患者的低周期值 (Ct) 和疾病严重程度之间的相关性存在误解.
研究的目的:
- 调查COVID-19患者中Ct值,临床特征和生物标志物之间的相关性.
- 评估Ct值的预后价值与已确定的生物标志物相比.
主要方法:
- 在印度西部的一个三级护理中心进行了一项跨度研究,持续了两年.
- 共有201名被诊断患有COVID-19的人被纳入研究.
- 收集的数据包括PCR测试中的Ct值,临床症状和各种生物标志物.
主要成果:
- 对E基因和RdRp基因的分析显示,很大一部分患者的Ct值较低.
- 常见的并发病包括糖尿病 (50%) 和高血压 (54.1%),大多数受影响的患者年龄在61-80.
- 在COVID阳性患者中观察到乳酸脱酶 (90.54%),前素 (79%) 和红细胞沉积率 (79.1%) 的升高水平.
结论:
- 周期值 (Ct) 值虽然具有研究实用性,但与已确定的生物标志物相比,对COVID-19的预后价值较差.
- 建议进行进一步的研究,以探索Ct值在持续病毒传播的背景下对预后的意义.
- 生物标志物对于评估COVID-19预后和指导临床管理至关重要.
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