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负面情绪状态的双向调节通过平行基因上不同的底侧杏仁体通道到腹状条纹体子区域的双向调节
Sarah E Sniffen1,2, Sang Eun Ryu1, Milayna M Kokoska1
1Department of Pharmacology and Therapeutics, Center for Smell and Taste, Gainesville, FL 32610, USA.
bioRxiv : the preprint server for biology
|July 1, 2024
概括
确定了涉及多巴胺受体D1和D2的明显的底侧杏仁体 (BLA) 神经元通路. 这些途径双向地影响情绪状态,为焦虑及其障碍提供了新的见解.
科学领域:
- 神经科学是一个神经科学.
- 行为神经科学 行为神经科学
- 分子精神病学分子精神病学
背景情况:
- 底侧杏仁体 (BLA) 含有多样化的细胞群,对于情绪处理和焦虑障碍至关重要.
- 包括表达Ppp1r1r1b的神经元在内的BLA刺激神经元都与情绪调节有关.
- 在情绪反应中表达BLA神经元的多巴胺受体D1 (drd1+) 和D2 (drd2+) 的特定作用在很大程度上是未知的.
研究的目的:
- 为了研究DRD1+和DRD2+BLA神经元群体在学习和不学习的情绪行为中的功能.
- 为了阐明这些独特的BLA神经元群体到腹状条纹体的投影路径.
- 确定这些通路的激活或抑制如何影响情绪状态.
主要方法:
- 对drd1+和drd2+ BLA神经元群体的识别和表征.
- 追踪BLA投射到腹状条纹体的痕迹.
- 使用三个不同的行为测试来评估情绪反应.
- 操纵特定BLA神经元群体的活动.
主要成果:
- Drd1+和drd2+ BLA神经元形成两个平行投射通道到腹状条纹体.
- 这些通路能够激发腹状条状体神经元.
- 这些通路的激活或抑制以一种投影特定的方式双向调节学习和未学习的情绪状态.
- 观察到drd1+和drd2+电路对负面情绪状态的独特贡献.
结论:
- 平行,基因上不同的BLA与腹状条纹体电路传达情绪状态.
- 这些电路以投影特定的方式影响情绪处理,为精细的情绪调节模型做出贡献.
- 这些发现为了解焦虑和相关疾病背后的神经回路提供了基础.
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