长期COVID的性别差异和免疫相关性 长期COVID的发展,持久性和解决方案
Rebecca E Hamlin1, Shaun M Pienkos1, Leslie Chan1,2
1Department of Medicine, Stanford University School of Medicine; Stanford, CA, USA.
bioRxiv : the preprint server for biology
|July 1, 2024
概括
性差异影响长期COVID (LC) 的发展. 这项研究揭示了男性和女性不同的免疫失调,为向的长期COVID治疗提供了洞察力.
科学领域:
- 免疫学 免疫学 免疫学
- 遗传学 遗传学 是一个
- 病毒学 病毒学
背景情况:
- 在COVID-19和长期COVID (LC) 结果中存在性别差异.
- 男性面临更高的急性感染严重程度,而女性不成比例地受到LC的影响.
- 性别特异性免疫失调被假设是驱动LC病变的原因.
研究的目的:
- 调查LC发展和持久性的免疫学基础.
- 确定LC的性别特异性和保存免疫相关物.
- 为开发定制的LC治疗提供洞察力.
主要方法:
- 采用了单细胞转录组学,单细胞蛋白组学和血蛋白组学.
- 分析了45名患者在急性SARS-CoV-2感染期间以及感染后3个月和12个月的血液样本.
- 将LC发病的患者与康复的患者进行比较.
主要成果:
- 发生LC的男性在急性感染期间在NK细胞中增加了TGF-β信号.
- 发生LC的女性在12个月后表现出XIST表达和IL1信号在单细胞中的增加.
- 患有LC的两种性别都减少了单细胞协同刺激信号,上调了NF-κB,增加了T细胞耗尽标志物LAG3,减少了ETS1,并在T细胞中增加了IL-4.
结论:
- 鉴定了多种LC的先天性和适应性免疫相关物,有些是性别特异的.
- 在患有LC的男性和女性中观察到不同的免疫特征.
- 这些发现表明,针对性别量身定制的LC治疗可能是潜在的治疗目标.
相关概念视频
01:23Immunological Memory
585
Immunological memory, a pivotal pillar of the adaptive immune system, is responsible for the body's ability to remember and respond more swiftly and effectively to previously encountered pathogens. This remarkable feature is what makes vaccines so effective in preventing diseases.
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
585
01:26Factors Affecting the Risk of Infection
11.6K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
11.6K
01:29Immune Response Against Viral Pathogens
771
The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
771
02:20Longitudinal Research
11.9K
Sometimes we want to see how people change over time, as in studies of human development and lifespan. When we test the same group of individuals repeatedly over an extended period of time, we are conducting longitudinal research. Longitudinal research is a research design in which data-gathering is administered repeatedly over an extended period of time. For example, we may survey a group of individuals about their dietary habits at age 20, retest them a decade later at age 30, and then again...
11.9K