青少年的酒精暴露促进了机械的全体运动,并改变了从底侧杏仁体到前皮层的输入中的突触功能
J Daniel Obray1, Erik T Wilkes1, Michael D Scofield1,2
1Department of Neuroscience, Medical University of South Carolina, Charleston, SC, 29425.
bioRxiv : the preprint server for biology
|July 1, 2024
概括
青少年间歇性乙醇暴露会通过改变大脑电路引起长期疼痛过敏. 这种过度饮酒模式扰乱了前临床皮质中的突触功能,影响了疼痛感知.
科学领域:
- 神经科学是一个神经科学.
- 成研究 研究成研究
- 疼痛感知 疼痛感知
背景情况:
- 青春期过度饮酒与不良健康结果有关,包括增加疼痛敏感性.
- 前肢 (PrL) 皮质,底侧杏仁体 (BLA) 和腹侧周水道灰色 (vlPAG) 是 nociception 中的关键大脑区域,并受到青少年酒精暴露的影响.
研究的目的:
- 研究青少年间歇性乙醇 (AIE) 暴露如何影响前额叶皮层的感觉回路中的突触功能和兴奋性.
- 确定AIE对BLA-PrL-vlPAG通路的影响及其在疼痛感知中的作用.
主要方法:
- 青少年间歇性乙醇 (AIE) 暴露在雄性和雌性大鼠中通过蒸汽吸入.
- 评估机械和热灵敏度,以确定疼痛感知中的变化.
- 光遗传学和切片电生理学结合反向体和病毒标记来分析PrL皮层内的特定神经元群体的突触功能.
主要成果:
- 暴露于AIE诱导了持续的机械体 (疼痛过敏症).
- AIE减少了向vlPAG投射的PrL神经元中的BLA驱动的前抑制,导致激发/抑制 (E/I) 平衡和内在刺激性增加.
- 在PrL帕瓦胺内神经元 (PVINs) 中,AIE暴露降低了E/I平衡和内在刺激能力.
结论:
- 青少年间歇性乙醇暴露显著改变突触功能和神经元刺激性在关键的前额头疼痛处理电路内.
- 在BLA-PrL-vlPAG通路中的这些神经适应可能有助于在青少年狂饮后观察到的疼痛感觉升高.
- 研究结果强调了青少年暴露于酒精的长期影响,影响疼痛回路和感知.
更多相关视频
06:09Wheel Running and Environmental Complexity as a Therapeutic Intervention in an Animal Model of FASD
Published on: February 2, 2017
6.8K
15:27Construction of Vapor Chambers Used to Expose Mice to Alcohol During the Equivalent of all Three Trimesters of Human Development
Published on: July 13, 2014
14.7K
相关概念视频
01:15Functional Brain Systems: Limbic System
2.5K
The limbic system, often called the "emotional brain," is a complex set of structures located deep within the brain. The intricate network of the limbic system supports a wide range of psychological functions, from emotional regulation to memory formation and sensory processing. This functional brain region encompasses specific parts of the diencephalon and the cerebrum, integrating the higher mental functions of the cerebral cortex with the primitive emotional responses of the deep brain...
2.5K
01:16Role of Amygdala in Memory
195
The amygdala is a small, almond-shaped structure responsible for processing and storing memories, particularly those linked to emotions like fear and stress. It plays an essential role in the brain's response to emotionally significant events and often enhances memory formation by triggering stress hormone release. The amygdala is vital for encoding and retrieving memories associated with fear or stress, a process that is adaptive by helping organisms avoid dangerous situations.
One of the...
One of the...
195