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Updated: Jun 22, 2025

Analyzing Tumor Gene Expression Factors with the CorExplorer Web Portal
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SMARCA4突变诱导了瘤细胞内在缺陷的增强器景观和对免疫治疗的抗性

Yawen Wang, Ismail M Meraz, Md Qudratullah

    bioRxiv : the preprint server for biology
    |July 1, 2024
    PubMed
    概括

    由于免疫细胞透率降低,SMARCA4缺乏的肺癌显示出免疫治疗反应不佳. 这是因为SMARCA4的损失会通过改变增强剂的可访问性和影响NF-κB活性来损害先天免疫基因表达.

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