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Updated: Jun 22, 2025

From a Natural Product to Its Biosynthetic Gene Cluster: A Demonstration Using Polyketomycin from Streptomyces diastatochromogenes Tü6028
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From a Natural Product to Its Biosynthetic Gene Cluster: A Demonstration Using Polyketomycin from Streptomyces diastatochromogenes Tü6028

Published on: January 13, 2017

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基质捕获在多基酸合成酶和酸酶域中:巨乳素形成的结构基础

Tyler M McCullough, Vishakha Choudhary, David L Akey

    bioRxiv : the preprint server for biology
    |July 1, 2024
    PubMed
    概括

    研究人员使用1,3-二氨基酸 (DAP) 来捕获中间体,设计了硫酶 (TEs),揭示了类抗生素支架的形成方式,并使生物催化剂的优化成为可能.

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