在健康和精神分裂症中的形态相似性网络的异质性
Joost Janssen1,2, Ana Guil Gallego1, Covadonga M Díaz-Caneja1,2,3
1Department of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón, Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Madrid, Spain.
bioRxiv : the preprint server for biology
|July 1, 2024
概括
精神分裂症患者在特定的大脑网络中表现出改变的形态相似性,但规范模型显示个人差异很少见. 纵向分析表明大多数患者的时间变化很小.
科学领域:
- 神经成像是一种神经成像.
- 精神病学神经科学 精神病学神经科学
- 大脑的连接性 大脑的连接性
背景情况:
- 形态相似性,一个神经成像表型,使用MRI参数量化区域间大脑连接.
- 之前的研究报告说,在群体层面上精神病障碍的平均形态相似性发生了变化,但具有显著的个体变化.
- 规范建模提供了一种方法来解决脑成像表型中的横截面和纵向异质性.
研究的目的:
- 通过使用规范建模来研究健康和精神分裂症的形态相似性的个体间异质性.
- 在预定义的大脑功能网络中评估形态相似性的横截面和纵向变化.
主要方法:
- 对62个皮质区域的形态学相似性从健康对照 (n=4310) 和慢性精神分裂症患者的T1加权MRI扫描中计算出来.
- 在健康的对照中,使用贝叶斯线性回归训练了规范模型,并考虑了年龄,性别,图像质量和扫描仪.
- 对每个参与者和大脑网络计算了个体偏差 (z-score) 和形态相似性的纵向变化.
主要成果:
- 精神分裂症患者在默认模式网络中表现出减少的形态相似性,并且在基线时在体运动网络中增加相似性.
- 很少有 (<6%) 患者表现出低于正常或高于正常的形态学相似值,与健康对照没有差异.
- 纵向分析显示,异常区域的数量在小组内变化很小,在小组之间没有显著差异.
结论:
- 默认模式网络中的形态相似度降低可能是精神分裂症的特定发现.
- 规范模型表明,显著的区域形态相似性减少和纵向变化仅在少数精神分裂症患者中存在.
- 这些发现强调了在解释精神分裂症中神经成像表型时考虑个体变异性的重要性.
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