在年轻人中,沿着感觉运动关联连接轴,结构性连接性成熟
Xiaoyu Xu1,2, Hang Yang2, Jing Cong1,2
1State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University; Beijing, 100875, China.
bioRxiv : the preprint server for biology
|July 1, 2024
概括
从童年到成年,大脑连接沿着感官运动关联轴发展. 这个等级轴显示了早期的感觉运动和晚期关联发展,影响认知和精神病理学.
科学领域:
- 神经科学是一个神经科学.
- 发育神经科学的发展神经科学.
- 脑部成像 脑部成像
背景情况:
- 童年和青春期涉及显著的大脑发育,特别是白质结构连接.
- 人类连接体中这种发育重塑的空间和时间模式尚未完全理解.
研究的目的:
- 研究人类连接体中白质结构连接的发育轨迹.
- 确定从童年到青春晚期大脑连接发展的空间和时间模式.
主要方法:
- 利用来自大规模横截面和纵向发育队列的非侵入性扩散MRI数据.
- 分析了与年龄,认知和精神病理学有关的结构性连接性发展.
主要成果:
- 从8.1岁到21.9岁,结构连接的发展遵循传感运动关联 (S-A) 轴.
- 观察到从幼儿时代增加的感觉运动-感觉运动连接到青少年晚期增加的关联-关联连接的连续性.
- S-A轴与高阶认知和一般精神病理学的变化相关.
结论:
- 揭示了管理人类大脑结构连接发展的等级轴.
- 这个发育轴为理解大脑成熟及其与认知和临床结果的关系提供了一个框架.
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