相关实验视频

Updated: Jun 22, 2025

Identifying Transcription Factor Olig2 Genomic Binding Sites in Acutely Purified PDGFRα+ Cells by Low-cell Chromatin Immunoprecipitation Sequencing Analysis
12:29

Identifying Transcription Factor Olig2 Genomic Binding Sites in Acutely Purified PDGFRα+ Cells by Low-cell Chromatin Immunoprecipitation Sequencing Analysis

Published on: April 16, 2018

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单细胞多基因组分析揭示了合作转录因子,用于对寡细胞的基因调节

Jerome J Choi, John Svaren, Daifeng Wang

    bioRxiv : the preprint server for biology
    |July 1, 2024
    PubMed
    概括

    这项研究揭示了转录因子 (TFs) 如何合作调节脑健康的关键细胞 - - 寡干细胞中的基因表达. 像SOX10-OLIG2这样的关键TF对被确定为对寡细胞功能和分化至关重要的.

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    Generation of Oligodendrocytes and Oligodendrocyte-Conditioned Medium for Co-Culture Experiments09:05

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    Generation of Human Neurons and Oligodendrocytes from Pluripotent Stem Cells for Modeling Neuron-Oligodendrocyte Interactions10:53

    Generation of Human Neurons and Oligodendrocytes from Pluripotent Stem Cells for Modeling Neuron-Oligodendrocyte Interactions

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    相关概念视频

    General Transcription Factors01:30

    General Transcription Factors

    Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
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    Master Transcription Regulators02:23

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    Cooperative Binding of Transcription Regulators02:13

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    Transcriptional regulators bind to specific cis-regulatory sequences in the DNA to regulate gene transcription. These cis-regulatory sequences are very short, usually less than ten nucleotide pairs in length. The short length means that there is a high probability of the exact same sequence randomly occurring throughout the genome.  Since regulators can also bind to groups of similar sequences, this further increases the chances of random binding. Transcriptional regulators form...
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    Combinatorial Gene Control02:33

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    Regulation of Expression at Multiple Steps01:23

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    Transcription Factors02:16

    Transcription Factors

    Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
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