从后面的方向盘:中央模式发电机的协调下行导航由上升的内部系统
Julius Jonaitis1, Karen L Hibbard2, Kaity McCafferty Layte1
1School of Psychology and Neuroscience, University of St Andrews, St Andrews, UK.
bioRxiv : the preprint server for biology
|July 1, 2024
概括
多虫幼虫的上升性内部神经元协调运动和导航. 这些神经元在运动神经元之后活跃,影响方向盘和气味导向运动.
科学领域:
- 神经科学是一个神经科学.
- 动物行为 动物行为
- 发展生物学 发展生物学
背景情况:
- 协调动物的运动对于生存和目标的实现至关重要.
- 了解控制运动和导航的神经回路是神经科学的一个关键挑战.
研究的目的:
- 描述Drosophila幼虫上升性内神经元的解剖学和功能.
- 研究这些神经元如何影响方向盘,导航和运动控制.
主要方法:
- 电子和光显微镜用于解剖学重建.
- 成像用于监测与运动神经元相关的神经元活动.
- 光遗传学操纵以评估孤立的中枢神经系统和行为的功能作用.
主要成果:
- 胆性19f细胞从前运动内神经元接收输入,并向前部部分投射.
- 19f神经元被招募到大多数运动程序中,活动滞后于运动神经元输出.
- 19f细胞的光遗传激活/抑制调节了探索性运动和前进运动.
- 改变的19f活动影响了嗅觉导航行为.
结论:
- 上升性内神经元监测运动活动,并塑造节奏发生器相互作用.
- 这些神经元在协调诸如导航之类的复杂行为方面发挥着特定于环境和位置的作用.
- 研究结果提供了关于运动协调和目标导向导航的基础神经机制的见解.
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