兴奋的noradrenergic调整与协调的运动运动相结合
Li Li1,2,3, Akshay N Rana1,2, Esther M Li1,2,4
1Departments of Anesthesiology and Pain Medicine, University of Washington, Seattle, WA 98195, USA.
bioRxiv : the preprint server for biology
|July 1, 2024
概括
部 (locus coeruleus,LC) 协调唤醒和运动. 腰椎激活与运动启动和兴奋有关,而停活与运动停止有关,揭示了它在运动-兴奋合中的作用.
科学领域:
- 神经科学是一个神经科学.
- 生理学 生理学 生理学
背景情况:
- 协调激发与运动活动对于认知和代谢资源分配至关重要.
- 连接唤醒和运动控制的大脑机制,特别是部 (LC) 的作用,尚未完全理解.
研究的目的:
- 为了调查座 (LC) 在调解唤醒和运动活动之间的合中的作用.
- 阐明LC北上腺素 (NE) 活性如何与运动启动,停止和兴奋状态有关.
主要方法:
- 生理学记录的记录.
- 纤维光度计是指光纤光度计.
- 视觉遗传学 视觉遗传学
- 行为跟踪 行为跟踪
主要成果:
- 慢性上腺素 (LC NE) 激活与在清醒期间恢复有组织的运动密切相关.
- 在清醒的动物中,LCNE的激活与运动启动相关,激活与运动停止相关.
- 随着麻醉的深度,LCNE活动会变化,它的光激活会增加同情性兴奋.
结论:
- 脑位 (locus coeruleus,LC) 在协调唤醒和运动活动方面发挥着重要作用.
- 脊髓中枢提供了运动输出和兴奋状态之间的关键联系,调节认知和代谢资源.
相关概念视频
Functional Brain Systems: Reticular Formation
1.8K
The reticular formation is a complex network of gray and white matter located within the brainstem extending from the medulla to the midbrain.
Within the reticular formation, there are several distinct nuclei that can be classified into three broad categories. The Raphe nuclei are located along the midline of the brainstem. They are primarily known for their role in synthesizing and releasing serotonin, a neurotransmitter involved in regulating mood, appetite, sleep, and circadian rhythms. The...
Within the reticular formation, there are several distinct nuclei that can be classified into three broad categories. The Raphe nuclei are located along the midline of the brainstem. They are primarily known for their role in synthesizing and releasing serotonin, a neurotransmitter involved in regulating mood, appetite, sleep, and circadian rhythms. The...
1.8K
Sleep-Wake Cycles
1.3K
Sleep is an essential physiological process vital to maintaining overall well-being. The reticular activating system (RAS), a network of neurons in the brainstem, regulates wakefulness and sleep. While it may seem passive, sleep consists of distinct cycles, each with its unique characteristics and functions. Two key sleep phases are non-rapid eye movement (NREM) and rapid eye movement (REM).
NREM Sleep
NREM sleep comprises four progressive stages that seamlessly merge:
NREM Sleep
NREM sleep comprises four progressive stages that seamlessly merge:
1.3K
Sympathetic Activation
5.3K
The sympathetic division can influence tissues and organs by releasing norepinephrine at peripheral synapses and distributing epinephrine and norepinephrine through the bloodstream. In times of crisis or stress, sympathetic activation occurs, which is regulated by sympathetic centers in the hypothalamus. As a result, sympathetic activation prepares the body for physical exertion, rapid ATP production, and heightened alertness, allowing individuals to respond effectively to challenging or...
5.3K
Optimal Arousal Theory
164
The optimal arousal theory suggests that performance is maximized when an individual experiences a moderate level of arousal. This theory is closely tied to the Yerkes-Dodson law, which illustrates an inverted U-shaped relationship between arousal and performance. The law, formulated by psychologists Robert Yerkes and John Dodson, implies an ideal arousal level for optimal performance, and deviations from this level can lead to declines in effectiveness.
Inverted U-Shaped Performance Curve
The...
Inverted U-Shaped Performance Curve
The...
164
Neural Regulation of Blood Pressure
2.7K
The neural regulation of blood pressure involves intricate interactions between the autonomic nervous system (ANS) and cardiovascular system, ensuring adequate perfusion of tissues. This regulation primarily occurs through baroreceptor and chemoreceptor reflexes, involving both short-term and long-term mechanisms.
Baroreceptor Reflex
Baroreceptors, located in the carotid sinuses and aortic arch, detect changes in blood pressure. When blood pressure rises, these stretch-sensitive receptors...
Baroreceptor Reflex
Baroreceptors, located in the carotid sinuses and aortic arch, detect changes in blood pressure. When blood pressure rises, these stretch-sensitive receptors...
2.7K
REM Sleep Behavior Disorder
179
REM Sleep Behavior Disorder (RBD) is a sleep disorder characterized by the absence of muscle paralysis that normally occurs during the REM phase of sleep. This absence allows individuals to physically act out their dreams, which are often vivid and disturbing. Common behaviors exhibited during episodes include kicking, punching, and yelling. These actions can be dangerous, potentially leading to injuries for the person with RBD or their bed partner.
RBD is significantly associated with...
RBD is significantly associated with...
179


