尿酸代谢物与慢性阻塞性肺病之间的关联:一个横截面研究
Xuefang Li1, Zhijun Li2, Jian Ye2
1Department of Infectious Diseases, Zhejiang Hospital, Hangzhou, People's Republic of China.
概括
尿路甲酸盐暴露,特别是MEHHP,与患慢性阻塞性肺病 (COPD) 和肺功能降低的风险更高有关. 像MBzP这样的其他酸盐与气流阻塞和咳相关.
科学领域:
- 环境健康 环境健康
- 肺部医学 肺部医学
- 毒理学 毒理学 毒理学
背景情况:
- 酸盐是常见的环境污染物.
- 暴露于甲酸盐与各种不良健康结果有关.
- 慢性阻塞性肺病 (COPD) 是一个主要的全球健康问题.
研究的目的:
- 调查尿甲酸代谢物和COPD之间的关联.
- 探索酸盐,空气流阻塞,肺功能和呼吸系统症状之间的关系.
主要方法:
- 在NHANES.中使用2023名成年人 (≥40岁) 的数据进行横截面研究.
- 多变量逻辑回归分析了11种尿甲酸代谢物和COPD,气流阻塞和呼吸道症状.
- 线性回归评估了甲酸盐代谢物与肺功能 (FEV1,FVC) 之间的关联.
主要成果:
- 较高的MEHHP水平与COPD风险增加有关 (OR:2.779),在男性中尤其明显.
- MCPP和MBzP与空气流阻塞风险有正相关性.
- MBzP与咳风险增加有关 (OR: 1.545).
- 一些酸盐,包括MEHHP,MECPP,MnBP,MEP,MiBP和MEOHP,与FEV1和FVC有负面关联.
结论:
- 升高的MEHHP水平与COPD和肺功能减弱 (FEV1,FVC) 的更高风险有关.
- MBzP与气流阻塞和咳有积极的关联,这表明潜在的呼吸系统健康影响.
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