各种吸入和鼻内皮质类固醇之间的感染风险比较:基于FAERS数据库的药监测分析
Ying Lan1, Die Hu1, Shijing Huang1
1Department of Pharmacy, Affiliated Hospital of Southwest Jiaotong University, The Third People's Hospital of Chengdu, Chengdu, Sichuan, 610031, People's Republic of China.
使用吸入性皮质类固醇 (ICS) 和鼻内皮质类固醇 (INC) 的女性面临更高的感染风险. 贝克洛米他显示出真菌和病毒感染的增加,而Fluticasone与肺炎和口腔候群病有关.
科学领域:
- 药物监督 药物监督 药物监督
- 临床药理学 临床药理学
- 呼吸系统医学 呼吸系统医学
背景情况:
- 吸入性皮质类固醇 (ICS) 和鼻内皮质类固醇 (INC) 广泛用于呼吸和过敏疾病.
- 了解与不同ICS/INC相关的比较感染风险对于患者安全至关重要.
- 以前的研究表明,皮质类固醇使用和感染之间存在潜在联系,但直接比较是有限的.
研究的目的:
- 进行药监测分析,比较与六种常见的ICS/INCs相关的感染风险:贝克洛米他,弗卢蒂卡,布德索尼德,西克莱索尼德,莫米塔和三氨酸.
- 为了确定与每个皮质类固醇相关的特定感染类型和身体部位.
- 用比例失衡分析评估ICS/INC与感染事件之间的相关性.
主要方法:
- 从2015年4月到2023年9月使用了FDA不良事件报告系统 (FAERS) 数据库.
- 采用比例失衡分析来评估ICS/INC与感染不良事件 (AE) 之间的关联.
- 分析了临床特征,感染部位和致病原体,用泡图可视化顶部感染AE.
主要成果:
- 分析了21,837个感染AE;61.14%报告在女性中,平均年龄62.12岁.
- 低呼吸道感染是常见的与Fluticasone,Budesonide,Ciclesonide和Mometasone. 氨酸与40%以上的眼部感染有关. 贝克洛梅他显示,口腔感染的发生率为7.39%.
- 贝克洛梅他的真菌 (21.15%) 和病毒 (19.2%) 感染率较高. 布德索尼德和西克莱索尼德分别显示了3.29%和2.03%的真菌细菌感染. ICS组显示出更多的真菌,口腔感染,肺炎和气管炎;INCs组显示出更多的眼睛症状,鼻炎,鼻炎和鼻炎.
结论:
- 使用ICS和INC的女性对感染事件的敏感性更高.
- 与布德索尼德相比,弗卢蒂卡松可能会增加肺炎和口腔角膜炎的风险.
- 莫梅他松可能与更多的上呼吸道感染有关,而贝克洛梅他松与口腔感染,真菌和病毒感染的风险更高有关. 西克莱索尼德和布德索尼德更频繁地与真菌菌菌感染有关.
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