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在椎脊椎病中大脑结构和功能的异常:基于voxel的多模式元分析
Lulu Cheng1,2, Jianxin Zhang1, Hongyu Xi3
1School of Foreign Studies, China University of Petroleum (East China), Qingdao, China.
Frontiers in neuroscience
|July 1, 2024
概括
这一元分析揭示了椎脊髓炎 (CS) 患者的一致的大脑变化,包括灰质体积和自发大脑活动的变化. 这些发现有助于理解CS病理生理学,并可能为诊断和治疗提供信息.
科学领域:
- 神经成像是一种神经成像.
- 放射学 放射学是指放射学
- 神经学 神经学
背景情况:
- 之前的研究表明,在椎脊髓炎 (CS) 中出现不一致的大脑异常.
- 像MRI这样的神经成像技术已经确定了CS患者的大脑结构和功能上的差异.
- 不同的结果需要全面的元分析来确定一致的变化.
研究的目的:
- 通过多模式元分析,研究CS患者的一致的结构和功能性大脑变化.
- 综合休息状态功能性MRI (rs-fMRI),结构MRI和扩散张力成像 (DTI) 研究的发现.
- 为了澄清CS的神经生物学基础.
主要方法:
- 在五个数据库中对相关的神经成像研究进行了系统的文献搜索.
- 包括的研究比较了CS患者和健康对照者 (HCs) 之间的大脑结构和功能.
- 对 rs-fMRI 和 VBM 数据进行了元分析,使用了无otropic 效应大小的签名差分映射软件.
主要成果:
- rs-fMRI分析显示,右舌环,右中环 (MTG),左下环和右后中环 (PoCG) 的活性下降,右中上额头环,双侧中额头环和右前环的活性增加.
- 基于voxel的形态测量 (VBM) 显示右上旋 (STG) 和右偏中叶 (PCL) 的灰质体积 (GMV) 增加,左补充运动区域和左MTG的GMV减少.
- 多模式分析表明,在CS患者的左PoCG,右STG和PCL中,GMV增加和自发大脑活动减少.
结论:
- 与HC相比,CS患者在GMV和区域自发大脑活动中表现出显著的变化.
- 改变的大脑区域包括主要视觉皮质,默认模式网络和感觉运动区域.
- 这些大脑变化可能与CS症状相关,例如感官缺陷,视力模糊,认知障碍和运动功能障碍,为诊断和治疗提供了见解.
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