相关实验视频

Updated: Jun 22, 2025

Quantitative Analysis of Cellular Composition in Advanced Atherosclerotic Lesions of Smooth Muscle Cell Lineage-Tracing Mice

Quantitative Analysis of Cellular Composition in Advanced Atherosclerotic Lesions of Smooth Muscle Cell Lineage-Tracing Mice

Published on: February 20, 2019

托科特里诺和托科菲罗 (维生素E) 对人类动脉样硬化心血管疾病的比较疗效

Saima Rafique¹, Dilshad Ahmed Khan², Kulsoom Farhat³

¹Department of Pharmacology and Therapeutics, Wah Medical College, Wah Cantt, National University of Medical Sciences, Rawalpindi, Pakistan.

JPMA. The Journal of the Pakistan Medical Association

|July 1, 2024

概括

托科特里诺,一种维生素E的形式,显示出显著的抗氧化功效,并改善心血管健康标志物. 它是一种比托科菲罗尔更安全,更有效的选择,用于治疗动脉样硬化心血管疾病.

科学领域:

营养生物化学营养生物化学
心血管医学心血管医学
分子生物学分子生物学

背景情况:

动脉样性心血管疾病 (ACVD) 是全球死亡的主要原因.
氧化应激和炎症在ACVD的发病过程中起着至关重要的作用.
维生素E,包括多科菲洛和多科特里诺,因其潜在的心脏保护作用而引起了人们的注意.

研究的目的:

系统地审查和比较托科特里诺尔与托科菲罗尔在治疗心血管疾病患者中的疗效.
评估这些维生素E形式对关键心血管风险因素和生物标志物的影响.

主要方法:

根据PRISMA 2020指南进行了系统审查.
文献搜索从2002年到2023年1月跨越主要科学数据库 (PubMed,谷歌学者,科克兰图书馆等). ) 的情况.
关键词包括"托科菲罗尔"",托科特里诺尔"",维生素E"",失脂血症"",心血管疾病"",心脏保护"",高胆固醇血清症"和"动脉样硬化".

主要成果:

托科特里昂醇 (250毫克/天) 显示出显著的抗氧化疗效,降低胆固醇,C-反应蛋白 (40%),马隆迪化物 (34%) 和马-氨基转移酶 (22%) (p<0.001).
托科醇增加了总抗氧化剂状态 (TAS) 的22% (p<0.001) 和降低了炎症类细胞因子 (抵抗素,IL-1,IL-12,IFN-γ) (p<0.05-0.01).
托科菲罗尔表现出异质的结果,对ACVD患者的死亡风险产生不一致的影响.

结论:

托科特里昂醇是一种安全有效的药物,可以改善心血管健康在ACVD管理中.
托科特里昂醇在减轻心血管风险因素和炎症方面,与托科菲罗尔相比,表现出更高的疗效.
需要进一步研究特定的托克烯醇异构体及其机制,包括微RNA调制.

关键词:

心血管疾病,维生素E,动脉样硬化,托科特里诺,失脂血症,托科菲罗,高胆固醇,人体研究.

更多相关视频

Quantification of Atherosclerosis in Mice

Quantification of Atherosclerosis in Mice

Published on: June 12, 2019

An In Vivo Estrogen Deficiency Mouse Model for Screening Exogenous Estrogen Treatments of Cardiovascular Dysfunction After Menopause

An In Vivo Estrogen Deficiency Mouse Model for Screening Exogenous Estrogen Treatments of Cardiovascular Dysfunction After Menopause

Published on: August 13, 2019

相关概念视频

Lipid-derived Compounds in the Human Body

Lipid-derived Compounds in the Human Body

Fats and lipids are crucial components in the human body. Some lipid-derived compounds, such as fat-soluble vitamins, eicosanoids, lipoproteins, and glycolipids, also play unique roles to support various biological processes .
Fat-soluble Vitamins
Fat-soluble vitamins, including vitamins A, D, E, and K, are required in minimal quantities, but their deficiencies can lead to severely abnormal physiological conditions. For example, vitamin A deficiency can cause night blindness, dry skin,...

Anticoagulant Drugs: Vitamin K Antagonists and Direct Oral Anticoagulants

Anticoagulant Drugs: Vitamin K Antagonists and Direct Oral Anticoagulants

Oral anticoagulants are vital tools in preventing and treating blood clotting disorders. This diverse class of medications can be categorized as vitamin K antagonists, exemplified by warfarin, and direct thrombin inhibitors (DTIs), such as dabigatran, as well as factor Xa inhibitors, including rivaroxaban.
Warfarin, a prominent vitamin K antagonist family member, exerts its effect by inhibiting the enzyme VKORC1 (vitamin K epoxide reductase complex 1). By hindering this enzyme, warfarin...

Dose-Response Relationship: Potency and Efficacy

Dose-Response Relationship: Potency and Efficacy

The potency of a drug is the measure of its ability to produce a biological response and can be compared by looking at the half-maximum effective concentration or EC50 values of different drugs. A lower EC50 value indicates higher potency of the drug. In the dose–response curve of two antihypertensive drugs, candesartan and irbesartan, a significant difference is observed in their EC50 values. A lower EC50 value for candesartan indicates that it is more potent than irbesartan, as it...