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Updated: Jun 22, 2025

Stereotaxic Microinjection of Viral Vectors Expressing Cre Recombinase to Study the Role of Target Genes in Cocaine Conditioned Place Preference
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无序但有效:作为过度兴奋性障碍的基因治疗点的简短线性图案

Sulayman D Dib-Hajj1,2,3, Stephen G Waxman1,2,3

  • 1Department of Neurology and.

The Journal of clinical investigation
|July 1, 2024
PubMed
概括

研究人员鉴定出一种型体,NaViPA1,它针对特定的通道 (Nav) 来减轻疼痛. 这一发现为慢性疼痛等过度兴奋性障碍提供了潜在的基因疗法.

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Ligand-gated ion channels are transmembrane proteins that play a vital role in intercellular communication and functions of the nervous system. They allow the influx of ions across the membrane once the neurotransmitter binds, allowing the subsequent transmission of electrical excitation across the neurons. Other ligand-gated ion channels, like the γ-aminobutyric acid (GABA) receptor, permit anions like chloride into the cells on the binding of the GABA molecule. Their entry into the cell...
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